In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis.
One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8βweeks. Adobe photoshop CS6 was used to measure the surface area of the lesions before treatment and after 8βweeks.
There was a highly statistically significant difference in the surface area of the lesions before and after treatment with topical diclofenac 1% gel (P = 0.001) but there was no statistically significant difference with topical ibuprofen gel (P = 0.057).
There was a highly significant difference between the 2 treatment regimens as regard the percentage of change in surface area of the lesions, with higher change in the diclofenc 1% gel treated group (P = 0.001). No patients complain from any side effect from either treatment.