Association Between Oral Corticosteroid Bursts and Severe Adverse Events

Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.. .. Background: Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown. Objective: To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart … Continue reading Association Between Oral Corticosteroid Bursts and Severe Adverse Events

#Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review

Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted.. Forty-two studies were included. We found a significant association of acne vulgaris with depression ( r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety ( r = 0.25 [95% confidence interval 0.19-0.31, P < .00001]). Subgroup analyses and comparisons showed … Continue reading #Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review

Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

..There was an increased risk of several cancers, including keratinocyte cancer (RR, 2.28; 95% CI, 1.73-3.01), lymphomas (RR, 1.56; 95% CI, 1.37-1.78), lung cancer (RR, 1.26; 95% CI, 1.13-1.40), and bladder cancer (RR, 1.12; 95% CI, 1.04-1.19). No increased risk of cancer for patients with psoriasis treated with biologic agents was found (RR, 0.97; 95% CI, 0.85-1.10). Psoriatic arthritis was not associated with increased risk … Continue reading Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

#Skin barrier damage after exposure to para-phenylenediamine

p-Phenylenediamine (#PPD) is a strong contact allergen used in hair dye known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in non-allergic occupational exposed individuals is unknown.. ..RNA-sequencing demonstrated down-regulation of tight junction (TJ) and stratum corneum (SC) proteins in skin of severe ACD patients after PPD exposure. Claudin-1 (CLDN1), claudin-8 (CLDN8), … Continue reading #Skin barrier damage after exposure to para-phenylenediamine

#Atopic eczema and #fracture risk in adults: A population-based cohort study

..Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity, with the strongest associations in people with severe eczema (compared … Continue reading #Atopic eczema and #fracture risk in adults: A population-based cohort study