Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

To investigate if the combination of biologics with methotrexate (MTX) would have better performance than biological monotherapy in clinical efficiency and safety for the treatment of psoriasis and psoriatic arthritis (PsA). Methods. A systematic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, and Embase was conducted. Psoriasis Area and Severity Index (PASI) responses (including PASI50,75 and 90), and proportion of patients … Continue reading Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

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Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients

Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overcome by changing the gut microbiota, this clinical trial evaluated the safety and efficacy of responder-derived fecal microbiota transplantation (FMT) together with anti–PD-1 in patients … Continue reading Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients

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Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures

Systemic and inhaled corticosteroids negatively affect bone remodeling and cause osteoporosis and bone fracture when given continuously or in high doses. However, risk of osteoporosis and major osteoporotic fracture (MOF) after application of topical corticosteroids (TCSs) is largely unexplored.. ..A total of 723 251 adults treated with the equivalent of at least 200 g of mometasone were included in the analysis (52.8% women; mean [SD] age, … Continue reading Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures

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Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea

Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin (PHT), oxcarbazepine (OXC), lamotrigine (LMT), zonisamide (ZNS), levetiracetam (LVT), and … Continue reading Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea

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Association Between #Atopic Eczema and #Cancer in England and Denmark

Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases cancer risk and that immune stimulation increases cancer risk. Establishing baseline cancer risk in people with atopic eczema is important before exploring the association between new biologic drugs for atopic eczema and cancer risk.. ..In England, matched cohorts included 471 970 individuals with atopic eczema (median [IQR] age, 41.1 [24.9-60.7] … Continue reading Association Between #Atopic Eczema and #Cancer in England and Denmark

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Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.

In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8 weeks. Adobe photoshop CS6 was used to measure the … Continue reading Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.

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Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action

Flushing and erythema are frequent skin symptoms in rosacea. Because their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.. ..Nine studies evaluating the use of carvedilol, propranolol, nadolol, and β-blockers in general were included. Articles studying carvedilol and propranolol showed a large reduction of erythema and flushing during treatment with a rapid onset of symptom control. Bradycardia and … Continue reading Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action

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Association Between Oral Corticosteroid Bursts and Severe Adverse Events

Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.. .. Background: Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown. Objective: To examine the associations between steroid bursts and severe adverse events, specifically gastrointestinal (GI) bleeding, sepsis, and heart … Continue reading Association Between Oral Corticosteroid Bursts and Severe Adverse Events

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#Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review

Several studies have shown an association of acne vulgaris with depression and anxiety, but a quantitative review has not yet been conducted.. Forty-two studies were included. We found a significant association of acne vulgaris with depression ( r = 0.22 [95% confidence interval 0.17-0.26, P < .00001]) and anxiety ( r = 0.25 [95% confidence interval 0.19-0.31, P < .00001]). Subgroup analyses and comparisons showed … Continue reading #Acne vulgaris and risk of #depression and #anxiety: A meta-analytic review

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Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

..There was an increased risk of several cancers, including keratinocyte cancer (RR, 2.28; 95% CI, 1.73-3.01), lymphomas (RR, 1.56; 95% CI, 1.37-1.78), lung cancer (RR, 1.26; 95% CI, 1.13-1.40), and bladder cancer (RR, 1.12; 95% CI, 1.04-1.19). No increased risk of cancer for patients with psoriasis treated with biologic agents was found (RR, 0.97; 95% CI, 0.85-1.10). Psoriatic arthritis was not associated with increased risk … Continue reading Prevalence, Incidence, and Risk of Cancer in Patients With #Psoriasis and Psoriatic Arthritis A Systematic Review and Meta-analysis

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#Skin barrier damage after exposure to para-phenylenediamine

p-Phenylenediamine (#PPD) is a strong contact allergen used in hair dye known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in non-allergic occupational exposed individuals is unknown.. ..RNA-sequencing demonstrated down-regulation of tight junction (TJ) and stratum corneum (SC) proteins in skin of severe ACD patients after PPD exposure. Claudin-1 (CLDN1), claudin-8 (CLDN8), … Continue reading #Skin barrier damage after exposure to para-phenylenediamine

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#Atopic eczema and #fracture risk in adults: A population-based cohort study

..Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity, with the strongest associations in people with severe eczema (compared … Continue reading #Atopic eczema and #fracture risk in adults: A population-based cohort study

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