Category: Dermatology

Dermatology

#Skin barrier damage after exposure to para-phenylenediamine

p-Phenylenediamine (#PPD) is a strong contact allergen used in hair dye known to cause allergic contact dermatitis (ACD). Both private and occupational exposure to PPD is frequent, but the effect of PPD exposure in non-allergic occupational exposed individuals is unknown.. ..RNA-sequencing demonstrated down-regulation of tight junction (TJ) and stratum corneum (SC) proteins in skin of severe ACD patients after PPD exposure. Claudin-1 (CLDN1), claudin-8 (CLDN8), … Continue reading #Skin barrier damage after exposure to para-phenylenediamine

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Dermatology, Orthopedy

#Atopic eczema and #fracture risk in adults: A population-based cohort study

..Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity, with the strongest associations in people with severe eczema (compared … Continue reading #Atopic eczema and #fracture risk in adults: A population-based cohort study

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