•Global & national AMR actions focus on infection prevention in healthcare settings.
•Home & everyday life settings contribute to acquiring & spreading AMR pathogens.
•Targeted hygiene protects against infections, reducing antibiotic prescribing.
• Targeted hygiene helps to minimize selection pressure for AMR development globally.
•Reducing AMR requires greater focus on targeted hygiene in the home & community.
Antimicrobial resistance (AMR) continues to threaten global health. Although global and national AMR action plans are in place, infection prevention and control is primarily discussed in the context of health care facilities with home and everyday life settings barely addressed. As seen with the recent global SARS-CoV-2 pandemic, everyday hygiene measures can play an important role in containing the threat from infectious microorganisms..