Question What is the comparative effectiveness of clopidogrel vs aspirin monotherapy in the chronic maintenance period after percutaneous coronary intervention (PCI) according to bleeding risk and procedural complexity?
Findings In this post hoc analysis of the HOST-EXAM Extended clinical trial, clopidogrel monotherapy was associated with a reduction in thrombotic and bleeding risks compared with aspirin, regardless of the presence of high bleeding risk and/or PCI complexity.
Meaning The study suggests that clopidogrel monotherapy can be a preferable choice over aspirin for secondary chronic maintenance therapy, irrespective of the bleeding risk and/or PCI complexity
https://jamanetwork.com/journals/jamacardiology/article-abstract/2826880
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