Key Points
Question In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?
Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated with a lower risk of ADRD. Furthermore, when HbA1c levels were out of range, greater time below individualized HbA1c target ranges was associated with increased risk of ADRD, even among individuals not prescribed agents associated with hypoglycemia.
Meaning These findings suggest that for older adults with diabetes, maintaining HbA1c stability in individualized target ranges over time is associated with a lower risk of ADRD
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2821878
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