..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine,… Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension
Although intensive blood pressure (BP)–lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH).. ..Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hypertension or elevated BP and that were 6 months or longer in duration. Trial… Continue reading Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension
Ultra-processed #food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project
Telomere length (TL) is a marker of biological age that may be affected by dietary factors through oxidation and inflammation mechanisms. In addition, ultra-processed food (UPF) consumption has increased worldwide and it has been associated with the risk of developing several diseases.. ..This is a cross-sectional study of 886 participants (645 men and 241 women)… Continue reading Ultra-processed #food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project
Association of #Hypertension With the Risk and Severity of #Epistaxis
..Among the 35 749 patients in the hypertension cohort (20 579 men [57.6%]; median age, 52 years [interquartile range, 45-62 years]) the incidence rate (IR) of epistaxis was 32.97 per 10 000 persons (95% CI, 30.57-35.51 per 10 000 persons); among the 35 749 individuals in the comparison cohort (20 910 men [58.5%]; median age, 52 years [interquartile range, 45-62 years]),… Continue reading Association of #Hypertension With the Risk and Severity of #Epistaxis
Robust T cell response towards spike, membrane, and nucleocapsid #SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients
T cell immunity towards SARS-CoV-2 spike (S), membrane (M), and nucleocapsid (N)-proteins might define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe, and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of all three proteins induce SARS-CoV-2-reactive T cell response with dominance of CD4+ over CD8+ T cells and… Continue reading Robust T cell response towards spike, membrane, and nucleocapsid #SARS-CoV-2 proteins is not associated with recovery in critical COVID-19 patients
Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection
Prior observational studies have suggested that fluoroquinolone use may be associated with more than 2-fold increased risk of aortic aneurysm or aortic dissection (AA/AD). These studies, however, did not fully consider the role of coexisting infections and the risk of fluoroquinolones relative to other antibiotics.. .. A total of 28 948 cases and 289 480 matched controls… Continue reading Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection
Effectiveness of a high volume injection as treatment for chronic #Achilles #tendinopathy: randomised controlled trial
.. Primary outcome was pain and function assessed using the validated Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire at 24 weeks (analysed using a generalised estimation equations model). Secondary outcomes were patient satisfaction, return to sport, degree of ultrasonographic Doppler flow, visual analogue scale on 10 hop test, power and flexibility of the gastrocnemius and… Continue reading Effectiveness of a high volume injection as treatment for chronic #Achilles #tendinopathy: randomised controlled trial
#Metabolic adaptation to #calorie restriction
Calorie restriction (CR) enhances health span (the length of time that an organism remains healthy) and increases longevity across species. In mice, these beneficial effects are partly mediated by the lowering of core body temperature that occurs during CR. Conversely, the favorable effects of CR on health span are mitigated by elevating ambient temperature to… Continue reading #Metabolic adaptation to #calorie restriction
Hepatic decompensation in #cirrhotic patients receiving antiviral therapy for chronic #hepatitis B
It is unclear if anti-hepatitis B virus (HBV) treatment can eliminate incident hepatic decompensation. Here we report the incidence and predictors of hepatic decompensation among cirrhotic patients receiving antiviral therapy for chronic hepatitis B.. ..818 patients (mean age, 54.9 years; 519 male [63.4%]) were included in the final analysis. During a mean follow-up of 58.1… Continue reading Hepatic decompensation in #cirrhotic patients receiving antiviral therapy for chronic #hepatitis B
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