The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the proximity of the gene encoding… Continue reading Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were… Continue reading Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis
Post-traumatic stress disorder (PTSD) has been identified as a potential risk factor for developing dementia. There are currently, however, no meta-analyses quantifying this risk.. ..PTSD was associated with a significant risk for all-cause dementia: pooled hazard ratio HR = 1.61 (95% CI 1.43–1.81, I2= 85.8%, P < 0.001; n = 1 693 678; 8 studies).… Continue reading Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis
#Aspirin use and risk of #breast cancer in African American women
Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed. Few studies have investigated these associations among African American women.. To assess the relation of aspirin use to risk of breast cancer in African American women,… Continue reading #Aspirin use and risk of #breast cancer in African American women
Depicting #SARS-CoV-2 faecal viral activity in association with #gut microbiota composition in patients with COVID-19
Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease course is largely unknown. We investigated temporal transcriptional activity of SARS-CoV-2 and its association with longitudinal faecal microbiome alterations in patients with COVID-19.. Seven (46.7%)… Continue reading Depicting #SARS-CoV-2 faecal viral activity in association with #gut microbiota composition in patients with COVID-19
Natural history of acute #kidney disease in patients with #cirrhosis
In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical… Continue reading Natural history of acute #kidney disease in patients with #cirrhosis
Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis
To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual… Continue reading Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis
It’s surprisingly nice to hear you: Misunderstanding the impact of #communication media can lead to suboptimal choices of how to connect with others.
Positive social connections improve wellbeing. Technology increasingly affords a wide variety of media that people can use to connect with others, but not all media strengthen social connection equally. Optimizing wellbeing, therefore, requires choosing how to connect with others wisely. We predicted that people’s preferences for communication media would be at least partly guided by… Continue reading It’s surprisingly nice to hear you: Misunderstanding the impact of #communication media can lead to suboptimal choices of how to connect with others.
Warmth Prevents #Bone Loss Through the Gut #Microbiota
Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of… Continue reading Warmth Prevents #Bone Loss Through the Gut #Microbiota
2 Medical News 