Ethnic influence on #nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016

Amongst the study population of 4538 persons, NAFLD prevalence was 32.5%, lowest in non‐Hispanic Blacks (18.0%) and Asians (18.1%), highest amongst Mexican Americans (48.4%). Within the NAFLD group, advanced fibrosis was highest in non‐Hispanic Blacks (28.5%) and lowest amongst non‐Hispanic Asians (2.7%). Of the 1473 (97.5%) NAFLD participants who answered NAFLD awareness question, 90% visited a healthcare centre at least once in the past year, … Continue reading Ethnic influence on #nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016

Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

We have shown that combination treatment with decaffeinated green tea extract (GTE) and voluntary exercise (Ex) reduces obesity and insulin resistance in high-fat (HF)-fed mice to a greater extent than either treatment alone. Here, we investigated the effects of GTE-, Ex- or the combination on the development of obesity-related NAFLD.. ..Combination treated, but not singly treated mice, had higher hepatic expression of genes related to … Continue reading Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

Unresolved issues of immune tolerance in chronic hepatitis #B

During the natural course of chronic hepatitis B virus infection, immune-tolerant phase is characterized by high viral replication, the presence of HBV e antigen (HBeAg), and normal or minimally elevated serum alanine aminotransferase. Immune-tolerant phase is usually regarded as a benign course of the disease. International guidelines recommend observation rather than treatment during immune-tolerant phase. In this article, we review unresolved issues related to the … Continue reading Unresolved issues of immune tolerance in chronic hepatitis #B

#Obesity Is the Most Common Risk Factor for Chronic #liver Disease

Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease.. ..We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity. Subjects were invited for a transient #elastography reading. A threshold of ≥8.0 kPa defined an elevated … Continue reading #Obesity Is the Most Common Risk Factor for Chronic #liver Disease

#Alcohol Consumption and Risk of Liver #Cirrhosis A Systematic Review and Meta-Analysis

..There was no increased risk for occasional drinkers. Consumption of one drink per day in comparison to long-term abstainers showed an increased risk for liver cirrhosis in women, but not in men. The risk for women was consistently higher compared to men. Drinking ≥5 drinks per day was associated with a substantially increased risk in both women (relative risk [RR] = 12.44, 95% confidence interval … Continue reading #Alcohol Consumption and Risk of Liver #Cirrhosis A Systematic Review and Meta-Analysis