Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) exist on a continuous spectrum in which fibrosis stage remains the dominant predictor of liver‑related complications. Contemporary non‑invasive risk stratification uses simple serum scores (e.g., Fibrosis‑4 index [FIB‑4]) as a first step, followed by vibration‑controlled transient elastography (VCTE) or liver‑specific blood… Continue reading Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Category: Hepatology
A new role of class A HBV capsid assembly modulators in core protein dynamics and cccDNA replenishment
Background & aims: Current treatments of chronic hepatitis B are rarely curative. Capsid assembly modulators (CAMs) target capsid formation by the hepatitis B virus (HBV) core protein. Class A CAMs (CAM-A) induce abnormal core protein assembly but how they affect core protein dynamics and inhibit HBV replication is only partially understood.Methods: Human liver chimeric mice… Continue reading A new role of class A HBV capsid assembly modulators in core protein dynamics and cccDNA replenishment
Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Introduction: Bacterial translocation and gut dysbiosis are key drivers of systemic immune activation in decompensated cirrhosis, precipitating inflammatory complications such as acute-on-chronic liver failure (ACLF). Currently, no licensed therapies effectively restore intestinal barrier function or reverse dysbiosis in this vulnerable population. While previous studies have suggested benefits of faecal microbiota transfer (FMT) in hepatic encephalopathy… Continue reading Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Hyponatremia as a Prognostic Marker in Cirrhosis: A Systematic Review of Its Role Beyond the Model for End-Stage Liver Disease in Predicting Mortality
This systematic review evaluates the prognostic significance of hyponatremia in patients with cirrhosis across diverse clinical settings. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science for studies published between January 2000 and December 2025, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a… Continue reading Hyponatremia as a Prognostic Marker in Cirrhosis: A Systematic Review of Its Role Beyond the Model for End-Stage Liver Disease in Predicting Mortality
Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Background and aims: Esophageal varices (EV) are a major complication of portal hypertension in decompensated chronic liver disease (DCLD), but endoscopy is invasive and resource-limited. This study assessed serum-ascites albumin gradient (SAAG) as a noninvasive predictor of EV occurrence and severity.Patients and methods: Prospective cross-sectional study (January 2023-May 2024) of 76 adults (≥18 years) with… Continue reading Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Efficacy and Long-Term Outcomes of Direct-Acting Antivirals in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Background/aims: The role of direct-acting antivirals (DAAs) in patients with hepatocellular carcinoma (HCC) remains uncertain due to conflicting data on virologic efficacy and long-term outcomes.Methods: This meta-analysis investigated studies reporting the sustained virologic response (SVR), recurrence, and overall survival in patients with HCC treated with DAAs.Results: Eighty-eight studies were included, comprising 8,839 patients with HCC… Continue reading Efficacy and Long-Term Outcomes of Direct-Acting Antivirals in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
Background & aims: Aminotransferases are widely used for metabolic dysfunction-associated steatotic liver disease (MASLD) evaluation, especially in type 2 diabetes mellitus (T2DM). Whether within-person seasonal variation affects classification near commonly used thresholds or relates to long-term metabolic outcomes remains unclear.Methods: This registry-based cohort analysed monthly aspartate aminotransferase (AST) and alanine aminotransferase (ALT) measurements from 6039… Continue reading Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
A retrospective study on the safety of small and large volume paracentesis and risk factors for adverse events in patients with gastrointestinal cancer with malignant ascites
Background: The optimal drainage volume for #paracentesis in malignant #ascites (MA) has not been established, and identifying risk factors for paracentesis may serve as a guideline for clinical decisions regarding drainage volume in MA patients. Therefore, the aim of this study is to compare the safety of small-volume drainage (SVD) versus large-volume drainage (LVD) in… Continue reading A retrospective study on the safety of small and large volume paracentesis and risk factors for adverse events in patients with gastrointestinal cancer with malignant ascites
Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches
Background: Hepatocellular carcinoma (#HCC ) is the most common primary liver tumor. Despite efforts to mitigate risk factors and implement surveillance programs in high-risk populations, such as screening, these strategies alone appear insufficient to significantly improve prognosis at diagnosis. The identification of novel prognostic factors remains an underdeveloped field that may play a key role… Continue reading Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches
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