Category: Gerontology

Gerontology

Predictors of a long length of stay in the emergency department for older people

..For older people, a long stay in the emergency department (ED) may reflect the complexity of their presentation, or deficiencies in systems that manage these complexities. ..Of 16 791 ED presentations made by older people, 4192 experienced a LLoS; 55% were admitted. Increasing age was associated with an increasing ED LoS. Factors most predictive of LLoS for both admitted and discharged patients included: investigations (both pathology … Continue reading Predictors of a long length of stay in the emergency department for older people

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Gerontology, Infectivology

Estimates of the severity of #coronavirus disease 2019: a model-based analysis

Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9–19·2) and to hospital discharge to be 24·7 days (22·9–28·1). In all laboratory confirmed and clinically diagnosed cases from mainland China (n=70 117), we estimated a crude case fatality ratio (adjusted … Continue reading Estimates of the severity of #coronavirus disease 2019: a model-based analysis

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Gerontology, Neurology

BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

Yongey Mingyur Rinpoche (YMR) is a Tibetan Buddhist monk, and renowned meditation practitioner and teacher who has spent an extraordinary number of hours of his life meditating. The brain-aging profile of this expert meditator in comparison to a control population was examined using a machine learning framework, which estimates “brain-age” from brain imaging. YMR’s brain-aging rate appeared slower than that of controls suggesting early maturation … Continue reading BrainAGE and regional volumetric analysis of a Buddhist monk: a longitudinal MRI case study

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Diet, Gerontology, Neurology

#Diet modulates brain network stability, a biomarker for brain #aging, in young adults

..One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive acuity. Effects emerged at 47 y, with the most rapid … Continue reading #Diet modulates brain network stability, a biomarker for brain #aging, in young adults

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Gerontology, Psychiatry

Decreasing #Delirium Through #Music: A Randomized Pilot Trial

To determine the feasibility and acceptability of personalized music (PM), slow-tempo music (STM), and attention control (AC) in patients receiving mechanical ventilation in an intensive care unit, and to estimate the effect of music on delirium.. ..Of the 1589 patients screened, 117 (7.4%) were eligible. Of those, 52 (44.4%) were randomized, with a recruitment rate of 5 patients per month. Adherence was higher in the … Continue reading Decreasing #Delirium Through #Music: A Randomized Pilot Trial

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Cardiology, Gerontology, Hypertension, Uncategorized

Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality

Blood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.. ..Risks of cardiovascular outcomes increased with SBPs >150 mmHg. Associations with mortality varied between non-frail <85 and … Continue reading Blood #pressure in frail older adults: associations with #cardiovascular outcomes and all-cause mortality

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Dentistry, Gerontology, Pneumology

#Periodontitis increases the risk of respiratory disease mortality in older patients

Evidence for an association between periodontitis and respiratory disease in the older patients is limited.. ..We found that periodontitis was associated with total respiratory disease mortality. Compared with healthy participants, the hazards ratio and 95% confidence interval for total respiratory disease mortality in patients with severe periodontitis was 2.72(1.04,7.11) after adjusting for relevant confounding variables. With increasing severity of periodontitis, risks for chronic obstructive pulmonary … Continue reading #Periodontitis increases the risk of respiratory disease mortality in older patients

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Gerontology, Orthopedy

#Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies

This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. ..Aspirin use was associated with a 17% lower odds for any fracture (OR 0.83, 95% CI 0.70 to 0.99; I2=71%; six studies; n=511 390). Aspirin was associated with a higher total hip BMD for women (SMD 0.03, 95% CI −0.02 to … Continue reading #Aspirin and #fracture risk: a systematic review and exploratory meta-analysis of observational studies

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Diet, Gastroenterology, Gerontology

#Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

..Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was associated with an increase in short/branch chained fatty acid production … Continue reading #Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

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Diet, Gerontology, Psychiatry

Association between #tea consumption and depressive symptom among Chinese older adults

Despite accumulating evidence on the protective effect of tea consumption against depression, studies specifically focusing on the elderly population are yet limited.. ..We found that consistent and frequent tea-drinking was associated with significantly less depressive symptoms, and such impact was partially mediated by socioeconomic status, health behavior, physical health, cognitive function, and social engagement. However, the association was only significant for males and the oldest-old, … Continue reading Association between #tea consumption and depressive symptom among Chinese older adults

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Cardiology, Gerontology

Associations between Serum Levels of #Cholesterol and #survival to Age 90 in Postmenopausal Women

Although elevated lipid levels predict increased risk of coronary heart disease and death in middle‐aged women and men, evidence is mixed if lipid levels measured in later life predict survival to very old ages.. HDL and LDL levels were not associated with survival to age 90 after adjustment for cardiovascular risk factors.. Similarly, no associations were observed between HDL and LDL levels and survival to … Continue reading Associations between Serum Levels of #Cholesterol and #survival to Age 90 in Postmenopausal Women

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Gerontology

#Handgrip strength variability during serial testing as an entropic biomarker of #aging: a Poincaré plot analysis

..An observational cross-sectional study was performed on 80 young adults (18–22 years old, mean age 20.01 years) and 80 older people (65–69 years old, mean age 67.13 years), with a sex ratio of 1:1 for both groups.. The analysis of the differences between groups revealed statistically significant results for most HGS-derived indices (p ≤ 0.05), and the magnitude of the differences indicated, in most situations, a large effect size (r > 0.5). Our … Continue reading #Handgrip strength variability during serial testing as an entropic biomarker of #aging: a Poincaré plot analysis

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