Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in …

Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes

Aims/IntroductionWe aimed to study the predictive ability of visit-to-visit variability in albuminuria for changes in renal function in patients with type 2 diabetes mellitus. Materials and MethodsThe cohort study was carried out in a single medical center. In the model development cohort of 1008 subjects, we developed the albuminuria variability score (AVS) to evaluate the visit-to-visit …

Continue reading Visit-to-visit variability in albuminuria predicts renal function deterioration in patients with type 2 diabetes

Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis

Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the hemodialysis population. Objective To investigate …

Continue reading Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis

Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease

Background & AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). MethodsThe participants were divided into four groups by the presence or absence of fatty liver disease (FLD) and metabolic dysfunction (MD). MAFLD was defined as having both FLD and MD, whereas CKD was defined as estimated glomerular …

Continue reading Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease

#Renal hemodynamics across the adult lifespan: Relevance of #flow pulsatility to chronic kidney disease

Elevated renal flow pulsatility may contribute to the pathogenesis of chronic kidney disease (CKD). The purpose of this study was to investigate the associations among age, renal flow pulsatility, and CKD biomarkers in non-CKD adults and CKD patients. MethodsNon-CKD adults (n = 415) and CKD patients (n = 136) aged between 22 and 83 years underwent the renal blood flow …

Continue reading #Renal hemodynamics across the adult lifespan: Relevance of #flow pulsatility to chronic kidney disease