Acute phosphate nephropathy (APN) is a rare but important cause of acute kidney injury (AKI), most commonly associated with the use of oral sodium phosphate bowel preparations administered prior to colonoscopy. In this report, we describe the case of a 60-year-old female patient who developed severe AKI necessitating temporary hemodialysis after bowel preparation with a… Continue reading Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation
Category: Nephrology
Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Objective: To determine whether fecal incontinence is associated with cardiovascular, pulmonary, and kidney disease, individually and in combination, and with all-cause mortality among community-dwelling US adults.Methods: Nationally representative cohort study using the National Health and Nutrition Examination Survey (NHANES) 2005-2010 with linkage to the National Death Index through December 31, 2019. The analytic cohort comprised… Continue reading Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Chaos in the Equilibrium: A Rare Complication of Dialysis
Dialysis disequilibrium syndrome (DDS) is a rare but potentially life-threatening neurologic complication associated with hemodialysis (HD), particularly during initial treatments in patients with severe uremia. It is thought to result from rapid osmotic shifts between the plasma and the central nervous system during dialysis. We present the case of a 36-year-old woman with stage V… Continue reading Chaos in the Equilibrium: A Rare Complication of Dialysis
Blood Pressure Phenotypes and Cardio-Kidney Outcomes: Findings From UK Biobank Data
Background: Hypertension is a leading cause of cardio-kidney outcomes (CKO). However, distinct blood pressure (BP) phenotypes and their effect on CKO remain underexplored. This study aimed to evaluate the independent contributions of BP phenotypes to CKO.Methods: This prospective, population-based study included UK Biobank participants enrolled between 2006 and 2010 with baseline systolic BP ≥90 mm… Continue reading Blood Pressure Phenotypes and Cardio-Kidney Outcomes: Findings From UK Biobank Data
Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Introduction: When a patient's presentation raises suspicions for conditions other than diabetic kidney disease (DKD), such as sudden onset proteinuria <5 years after the onset of type 2 diabetes, proteinuria without retinopathy or neuropathy, acute kidney injury, active urinary sediment, or hematuria, clinically indicated kidney biopsies are typically carried out. Consequently, a high incidence of… Continue reading Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Aims/hypothesis: Blood #pressure variability (BPV) is a risk factor for #kidney disease progression in hypertension and type 2 diabetes; however, the role of BPV in kidney disease in type 1 diabetes is unknown. The aim of this study was therefore to determine whether BPV has an impact on kidney disease progression in an ethnically diverse… Continue reading The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes
Clinicopathologic characteristics and long-term outcomes in glomerulonephritis with crescent formation: a 20-year single-center cohort study
IntroductionCrescentic #glomerulonephritis (GN) is among the most aggressive glomerular diseases, defined by extensive crescent formation and rapid loss of kidney function.ObjectiveTo evaluate clinical, laboratory, and histopathologic determinants of end-stage kidney disease (ESKD) and overall survival (OS), and to identify associated factors of poor outcomes in patients with crescentic GN (cGN) and GN with crescent formation.MethodsThis… Continue reading Clinicopathologic characteristics and long-term outcomes in glomerulonephritis with crescent formation: a 20-year single-center cohort study
Kidney function and all-cause mortality in the oldest-old population: a three-cohort longitudinal study
With increasing global life expectancy, the prognostic significance of #kidney function in centenarians and supercentenarians should be clarified. The conventional estimated glomerular filtration rate ( #eGFR ) threshold of < 60 mL/min/1.73 m2 may not accurately reflect chronic kidney disease (CKD) in this population, highlighting the need for age-adapted definitions. This study investigated the association… Continue reading Kidney function and all-cause mortality in the oldest-old population: a three-cohort longitudinal study
Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
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