EMA advises continued use of medicines for #hypertension, heart or #kidney disease during COVID-19 pandemic

EMA is aware of recent media reports and publications which question whether some medicines, for instance angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs, or sartan medicines), could worsen coronavirus disease (COVID-19). ACE inhibitors and ARBs are most commonly used for treating patients with high blood pressure, heart failure or kidney disease. It is important that patients do not interrupt their treatment with … Continue reading EMA advises continued use of medicines for #hypertension, heart or #kidney disease during COVID-19 pandemic

Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization

To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1) implant infection, 2.34 (95% CI, 1.87, 2.93); (2) transfusion, 2.46 … Continue reading Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization

Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD

Exposure to particulate matter (PM) <2.5 μm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD.. urinary albumin-creatinine ratio (UACR) ..There was no significant PM2.5-eGFR association at baseline. Each 1-μg/m3 higher annual average PM2.5 was associated with higher UACR after adjusting … Continue reading Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD

Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study

..Comorbid diseases and aging-related conditions were both more common among individuals experiencing acute kidney injury. However, after multivariable adjustment, no aging-related conditions were retained. There were 11 risk factors in the final model; the strongest were heart failure on presentation (odds ratio [OR] 1.91; 95% confidence interval [CI], 1.41-2.59), body mass index [BMI] >30 (vs BMI 18-25: OR 1.75; 95% CI, 1.27-2.42), and nonwhite race … Continue reading Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study

Retrospective cohort study of individuals born with low #birthweight: implications for screening practices

Previous studies have established an association between low birthweight (LBW) and future kidney disease, but few have explored the progression of kidney dysfunction through the pediatric years leading up through adolescence and young adulthood ..glomerular filtration rate (#GFR) between LBW (<2500 grams) and normal birthweight (NBW) Age at follow-up ranged 1–26 years old. GFR was found to be significantly lower in participants born with LBW … Continue reading Retrospective cohort study of individuals born with low #birthweight: implications for screening practices

Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR

People receiving their first opioid prescription were propensity matched to people receiving NSAIDS (and, in sensitivity analysis, gabapentinoids) and the risk of death and hospitalization were compared, classifying opioid medication exposure as time-varying daily oral morphine milligram equivalents (MMEs) across time-varying eGFR. Prescriptions for 1–59 and ≥60 MMEs were associated with higher risk of death .. and hospitalization.. compared with NSAID prescriptions, when evaluated at … Continue reading Associations of #Opioid Prescriptions with Death and Hospitalization across the Spectrum of Estimated #GFR

Healthy Dietary Patterns and Incidence of CKD. A Meta-Analysis of Cohort Studies

Healthy dietary patterns typically encouraged higher intakes of vegetables, fruit, legumes, nuts, whole grains, fish and low-fat dairy, and lower intakes of red and processed meats, sodium, and sugar-sweetened beverages. A healthy dietary pattern was associated with a lower incidence of CKD (odds ratio [OR] 0.70 (95% confidence interval [95% CI], 0.60 to 0.82); I2=51%; eight studies), and incidence of albuminuria (OR 0.77, [95% CI, … Continue reading Healthy Dietary Patterns and Incidence of CKD. A Meta-Analysis of Cohort Studies