#Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial

Intravenous zoledronate reduces fracture risk (5mg at 18mo intervals) and prevents bone loss (doses of 1-5mg for 3 to >5y), but the duration of action of a single 5mg dose and the effects of lower doses beyond 5 years are unknown. We report the second open-label extension (years 5-10) of a 2y randomized, multidose, placebo-controlled, double-blinded …

Continue reading #Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial

Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial

Osteolysis causes recurrent pain and disability after total hip arthroplasty. We investigated the effect of the human monoclonal antibody denosumab on osteolytic lesion activity in patients undergoing revision total hip arthroplasty surgery to show the biological proof of concept for a non-surgical treatment for the disease.. Findings Between Dec 12, 2012, and June 24, 2018, …

Continue reading Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial

#Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study

There is limited prospective evidence on possible differences in fracture risks between vegetarians, vegans, and non-vegetarians. We aimed to study this in a prospective cohort with a large proportion of non-meat eaters.. ..Compared with meat eaters and after adjustment for socio-economic factors, lifestyle confounders, and body mass index (BMI), the risks of hip fracture were …

Continue reading #Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study

Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort

To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Patients and Methods: Observational nested case–control study was conducted in Aragon, Spain in 2010. We included COPD patients aged > 40 years, in the EpiChron cohort. Each COPD patient was matched for …

Continue reading Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort

Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis

Musculoskeletal pain is a common cause of pain in adolescence and can be an important predictor of future pain. The prevalence of hip or groin pain that could potentially affect different adolescent populations has not yet been systematically reviewed. This systematic review aimed to determine the prevalence of hip or groin pain in this population. …

Continue reading Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis