Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure. MethodsWe did a meta-analysis of individual participant-level data from 48 … Continue reading Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

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KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea

Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecular mechanisms of action. The KCNQ5 voltage-gated potassium channel contributes to vascular smooth muscle tone and neuronal M-current regulation. Methods: We applied electrophysiology, myography, mass spectrometry and in silico docking to determine effects and their underlying … Continue reading KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea

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Evaluation of Optimal #Diastolic Blood #Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg

Extremely low diastolic blood pressure has been reported to be associated with increased adverse cardiovascular events (ie, the diastolic J-shape phenomenon); however, current US guidelines recommend an intensive blood pressure target of less than 130/80 mm Hg without mentioning the lower limits of diastolic blood pressure. Objectives To evaluate whether there is a diastolic J-shape phenomenon for patients with an treated systolic blood pressure of … Continue reading Evaluation of Optimal #Diastolic Blood #Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg

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Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study

Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI). Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913, who performed a maximum exercise test at age 54 years, … Continue reading Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study

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The global epidemiology of #hypertension

Hypertension is the leading cause of cardiovascular disease and premature death worldwide. Owing to the widespread use of antihypertensive medications, global mean blood pressure (BP) has remained constant or has decreased slightly over the past four decades. By contrast, the prevalence of hypertension has increased, especially in low- and middle-income countries (LMICs). Estimates suggest that 31.1% of adults (1.39 billion) worldwide had hypertension in 2010. … Continue reading The global epidemiology of #hypertension

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Association between circulating #vascular-related microRNAs and an increase in blood #pressure: a 5-year longitudinal population-based study

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and play essential roles in the pathogenesis of cardiovascular disease. Previous cross-sectional studies showed that the levels of several circulating miRNA are associated with hypertension, but there are no prospective longitudinal studies using a general population. The aim of this study is to evaluate the impact of circulating vascular-related miRNA (miR-126, miR-221, and miR-222) on … Continue reading Association between circulating #vascular-related microRNAs and an increase in blood #pressure: a 5-year longitudinal population-based study

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Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting

We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good … Continue reading Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting

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#Walking Volume and Speed Are Inversely Associated With Incidence of Treated #Hypertension in #Postmenopausal Women

Few studies have evaluated hypertension incidence in relation to walking, which is a common physical activity among adults. We examined the association between walking and hypertension incidence in 83 435 postmenopausal women who at baseline were aged 50 to 79 years, without known hypertension, heart failure, coronary heart disease, or stroke, and reported the ability to walk at least one block without assistance. Walking volume (metabolic … Continue reading #Walking Volume and Speed Are Inversely Associated With Incidence of Treated #Hypertension in #Postmenopausal Women

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Dietary Approaches to Stop #Hypertension Dietary Intervention Improves Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure

This randomized control trial assessed the post-intervention and 18-month follow-up effects of a 6-month dietary approaches to stop hypertension (DASH)-focused behavioral nutrition intervention, initiated in clinic with subsequent telephone and mail contact, on blood pressure (BP) and endothelial function in adolescents with elevated BP. Adolescents (n=159) 11 to 18 years of age with newly diagnosed elevated BP or stage 1 hypertension treated at a hospital-based … Continue reading Dietary Approaches to Stop #Hypertension Dietary Intervention Improves Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure

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Polypill with or without Aspirin in Persons without #Cardiovascular Disease

..Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or placebo daily, aspirin (75 mg) or placebo daily, and vitamin D or placebo monthly. We report here the outcomes for the polypill alone … Continue reading Polypill with or without Aspirin in Persons without #Cardiovascular Disease

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#Smoking Cessation, #Weight Change, #Diabetes, and #Hypertension in Korean Adult

This study investigates the association of smoking cessation and postcessation weight gain with the development of type 2 diabetes mellitus and hypertension. Methods A total of 96,524 individuals without diabetes mellitus and hypertension aged ≥20 years between 2006 and 2008 were included, with follow-up until December 31, 2015. Smoking status and weight changes were monitored for 2 years. Hazard ratios and 95% CIs were calculated … Continue reading #Smoking Cessation, #Weight Change, #Diabetes, and #Hypertension in Korean Adult

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#Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes

In EMPA‐REG MET, in patients with type 2 diabetes mellitus (T2DM) on stable background metformin (≥1500 mg/day), empagliflozin versus placebo significantly improved glycated haemoglobin (HbA1c), body weight (BW), and systolic blood pressure (SBP) over 24 and ≤76 weeks. This analysis investigated empagliflozin treatment effects by baseline cardio‐metabolic factors.. ..In total, 637 patients (56.7% males; mean [SD] age 55.7 [9.9] years, HbA1c 7.9 [0.9] %, BW 81.2 … Continue reading #Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes

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