Depression has been reported to be a risk factor for acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke typeMethodsINTERSTROKE is an international case-control study of risk …
Continue reading Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Objective To synthesise the evidence on the effects of physical activity on symptoms of depression, anxiety and psychological distress in adult populations.Design Umbrella review.Data sources Twelve electronic databases were searched for eligible studies published from inception to 1 January 2022.Eligibility criteria for selecting studies Systematic reviews with meta-analyses of randomised controlled trials designed to increase …
Reducing the duration of untreated psychosis (DUP) is essential to improving outcomes for people with first-episode psychosis (FEP). Current US approaches are insufficient to reduce DUP to international standards of less than 90 days.Objective To determine whether population-based electronic screening in addition to standard targeted clinician education increases early detection of psychosis and decreases DUP, …
Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the …
Continue reading Gut microbiome-wide association study of depressive symptoms
...Recommendation 1a:ACP recommends monotherapy with either cognitive behavioral therapy or a second-generation antidepressant as initial treatment in patients in the acute phase of moderate to severe major depressive disorder (strong recommendation; moderate-certainty evidence).Recommendation 1b:ACP suggests combination therapy with cognitive behavioral therapy and a second-generation antidepressant as initial treatment in patients in the acute phase of …
2Medical.News 