Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies

In some studies comparing triple with dual combination therapies in COPD there might be a possible effect of inhaler bias resulting from different inhaler devices being used in comparator arms. The aim of this study was a quantitative synthesis by considering the studies that directly compared triple ICS/LABA/LAMA vs. either dual LABA/LAMA or ICS/LABA therapies …

Continue reading Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies

Predictors of hospital readmission after fractures: One-year follow-up study

OBJECTIVE: Identify the incidence and predictive factors for readmissions of elderly hospitalized with fractures.METHOD: Prospective cohort study on 376 elderly people from a trauma referral large hospital in central Brazil. Data were collected from medical records of elderly people with radiological diagnosis of fractures. Readmission that occurs up to one year after the first discharge …

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Clustering of COPD patients and their response to pulmonary rehabilitation

Background and objectivePulmonary rehabilitation (PR) is fundamental in the management of chronic obstructive pulmonary disease (COPD). COPD patients show a large clinical heterogeneity that may influence their response to PR. Identification of homogeneous clusters of patients who may or may not respond to PR is important to personalize patient care. This study aimed at identifying …

Continue reading Clustering of COPD patients and their response to pulmonary rehabilitation

Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey

Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. MethodsThis was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used …

Continue reading Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey

When to Use Initial Triple Therapy in #COPD: Adding a LAMA to ICS/LABA by Clinically Important Deterioration Assessment

Triple therapy versus dual therapy for chronic pulmonary obstructive disease (COPD) can reduce symptoms, limit the risk of acute exacerbations (AEs) as well as improve lung function. Currently, studies that feature clinically important deterioration (CID) as a composite endpoint to assess the need for treatment intensification for patients maintained on dual therapy remained to be …

Continue reading When to Use Initial Triple Therapy in #COPD: Adding a LAMA to ICS/LABA by Clinically Important Deterioration Assessment