#Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults

Thunderstorm-related atmospheric changes are expected to increase in severity with rising global temperatures. Although large-scale evidence is limited, vulnerable populations, such as older adults or those with common chronic respiratory diseases, like asthma or chronic obstructive pulmonary disease (COPD), are expected to be susceptible to negative health effects from these changes.The objective of this study was to determine whether increases in emergency department (ED) visits … Continue reading #Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults

Randomized Trial of Nocturnal #Oxygen in Chronic #Obstructive Pulmonary Disease

Long-term oxygen therapy improves survival in patients with chronic obstructive pulmonary disease (COPD) and chronic severe daytime hypoxemia. However, the efficacy of oxygen therapy for the management of isolated nocturnal hypoxemia is uncertain.. ..Patients with an oxygen saturation of less than 90% for at least 30% of the recording time on nocturnal oximetry were assigned, in a 1:1 ratio, to receive either nocturnal oxygen or … Continue reading Randomized Trial of Nocturnal #Oxygen in Chronic #Obstructive Pulmonary Disease

Interstitial #lung abnormalities and the clinical course in patients with #COPD

The presence and progression of interstitial lung abnormalities (ILA) is known to be associated with a decline of lung function and increased risk of mortality. Research question We aimed to elucidate the clinical course according to ILA in patients with chronic obstructive pulmonary disease (COPD).. ..Of 363 patients with COPD, 44 and 103 patients had equivocal and definite ILA, respectively. Patients with ILA were significantly … Continue reading Interstitial #lung abnormalities and the clinical course in patients with #COPD

Factors associated with #sleep disturbance in patients with chronic #obstructive pulmonary disease

Poor sleep quality in patients with chronic obstructive pulmonary disease (#COPD ) has been associated with poor health outcomes. However, there is a lack of research on factors associated with sleep disturbance in patients with COPD.. This was a prospective, multicenter cross‐sectional study enrolling a sample of 245 COPD subjects. All patients completed the patient‐reported measure, the COPD and Asthma Sleep Impact Scale (CASIS) to … Continue reading Factors associated with #sleep disturbance in patients with chronic #obstructive pulmonary disease

Mid-Term Effects of Pulmonary #Rehabilitation on Cognitive Function in People with Severe Chronic Obstructive #Pulmonary Disease

Cognitive dysfunction is a common impairment associated with COPD. However, little is known about 1) its prevalence among those subjects referred for pulmonary rehabilitation (PR), 2) how it may affect the benefit of PR, 3) whether PR improves cognitive function and 4) whether cognitive dysfunction affects the usability of telehealth technology usually used to deliver in-home PR.. ..Mild cognitive dysfunction was found in 41 subjects … Continue reading Mid-Term Effects of Pulmonary #Rehabilitation on Cognitive Function in People with Severe Chronic Obstructive #Pulmonary Disease

Chronic #obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study

There has been limited evidence for the association between chronic obstructive pulmonary disease (COPD) and the incidence of lung cancer among never smokers. We aimed to estimate the risk of lung cancer incidence in never smokers with COPD, and to compare it with the risk associated with smoking. This cohort study involved 338 548 subjects, 40 to 84 years of age with no history of lung … Continue reading Chronic #obstructive pulmonary disease and lung cancer incidence in never smokers: a cohort study

#Periodontitis increases the risk of respiratory disease mortality in older patients

Evidence for an association between periodontitis and respiratory disease in the older patients is limited.. ..We found that periodontitis was associated with total respiratory disease mortality. Compared with healthy participants, the hazards ratio and 95% confidence interval for total respiratory disease mortality in patients with severe periodontitis was 2.72(1.04,7.11) after adjusting for relevant confounding variables. With increasing severity of periodontitis, risks for chronic obstructive pulmonary … Continue reading #Periodontitis increases the risk of respiratory disease mortality in older patients

Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis

..Compared with placebo or management without antibiotics, antibiotics given for 3 to 14 days were associated with increased exacerbation resolution at the end of the intervention (odds ratio [OR], 2.03 [95% CI, 1.47 to 2.80]; moderate SOE) and less treatment failure at the end of the intervention (OR, 0.54 [CI, 0.34 to 0.86]; moderate SOE), independent of severity of exacerbations in out- and inpatients. Compared … Continue reading Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis

Lung #MRI as a Potential Complementary Diagnostic Tool for Early #COPD

Many knowledge gaps in the nature of early chronic obstructive pulmonary disease (COPD) still exist, mainly because COPD has always been considered a disease of the elderly. Little attention has been paid to the pathologic changes in the lungs of young adults with risk factors for COPD, such as bronchopulmonary dysplasia. One major limitation is the current lack of noninvasive ways to sensitively measure or … Continue reading Lung #MRI as a Potential Complementary Diagnostic Tool for Early #COPD

Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers

..In adjusted analysis, a 5-ppb (parts per billion) increase in ozone concentration was associated with a greater percentage of emphysema (β = 0.94; 95% CI, 0.25-1.64; P = .007) and percentage of air trapping (β = 1.60; 95% CI, 0.16-3.04; P = .03); worse scores for the mMRC Dyspnea Scale (β = 0.10; 95% CI, 0.03-0.17; P = .008), CAT (β = 0.65; 95% CI, 0.05-1.26; P = .04), and SGRQ (β = 1.47; 95% CI, 0.01-2.93; P = .048); lower FEV1% predicted value (β = −2.50; … Continue reading Association of Long-term Ambient #Ozone Exposure With Respiratory Morbidity in #Smokers

Comparisons of exacerbations and mortality among regular inhaled therapies for patients with stable chronic obstructive pulmonary disease: Systematic review and Bayesian network meta-analysis

..Compared with placebo, all drug classes significantly reduced the total exacerbations and moderate to severe exacerbations. ICS/LAMA/LABA was the most efficacious treatment for reducing the exacerbation risk (odds ratio [OR] = 0.57; 95% credible interval [CrI] 0.50–0.64; posterior probability of OR > 1 [P(OR > 1)] < 0.001). In addition, in contrast to the other drug classes, ICS/LAMA/LABA and ICS/LABA were associated with a significantly … Continue reading Comparisons of exacerbations and mortality among regular inhaled therapies for patients with stable chronic obstructive pulmonary disease: Systematic review and Bayesian network meta-analysis

C-Reactive Protein Testing to Guide Antibiotic Prescribing for #COPD Exacerbations

Point-of-care testing of C-reactive protein (#CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD). A lower percentage of patients in the CRP-guided group than in the usual-care group received an antibiotic prescription at the initial consultation (47.7% vs. 69.7%, for a difference of 22.0 percentage points; adjusted odds ratio, 0.31; … Continue reading C-Reactive Protein Testing to Guide Antibiotic Prescribing for #COPD Exacerbations