Evidence is limited regarding the association between low-carbohydrate diet (LCD) score and mortality among Asians, a population that consumes a large amount of carbohydrates.. ..A U-shaped association was observed between LCD score and total mortality: the multivariable-adjusted hazard ratios (HRs) (95% CI) of total mortality for lowest through highest scores were 1.00, 0.95 (0.91, 1.01),… Continue reading Low #carbohydrate diet and all cause and cause-specific #mortality
Category: Cardiology
#Anticoagulation Timing in Cardioembolic #Stroke and Recurrent Event Risk
Guidelines recommend initiating anticoagulation within 4 to 14 days after cardioembolic stroke. Data supporting this did not account for key factors potentially affecting the decision to initiate anticoagulation, such as infarct size, hemorrhagic transformation, or high‐risk features on echocardiography.. ..We pooled data from stroke registries of 8 comprehensive stroke centers across the United States. We included… Continue reading #Anticoagulation Timing in Cardioembolic #Stroke and Recurrent Event Risk
Interventions to Improve #Statin Tolerance and Adherence in Patients at Risk for #Cardiovascular Disease
Strategies to improve patients' tolerance of and adherence to statins may enhance the effectiveness of dyslipidemia treatment in those at risk for cardiovascular disease (CVD).. ..One SR, 1 RCT, and 4 cohort studies were included. The SR found that intensified patient care improved adherence and decreased levels of total serum cholesterol and low-density lipoprotein cholesterol… Continue reading Interventions to Improve #Statin Tolerance and Adherence in Patients at Risk for #Cardiovascular Disease
Association of #Hypertension With the Risk and Severity of #Epistaxis
..Among the 35 749 patients in the hypertension cohort (20 579 men [57.6%]; median age, 52 years [interquartile range, 45-62 years]) the incidence rate (IR) of epistaxis was 32.97 per 10 000 persons (95% CI, 30.57-35.51 per 10 000 persons); among the 35 749 individuals in the comparison cohort (20 910 men [58.5%]; median age, 52 years [interquartile range, 45-62 years]),… Continue reading Association of #Hypertension With the Risk and Severity of #Epistaxis
Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection
Prior observational studies have suggested that fluoroquinolone use may be associated with more than 2-fold increased risk of aortic aneurysm or aortic dissection (AA/AD). These studies, however, did not fully consider the role of coexisting infections and the risk of fluoroquinolones relative to other antibiotics.. .. A total of 28 948 cases and 289 480 matched controls… Continue reading Association of Infections and Use of #Fluoroquinolones With the Risk of Aortic #Aneurysm or Aortic Dissection
Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos
Rationale: Sleep disorders are associated with hypertension and diabetes, primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanics/Latinos, in whom cardiovascular death is the leading cause of mortality. Objectives: To investigate the prospective associations of sleep disordered breathing (SDB) and insomnia with incident hypertension and diabetes among… Continue reading Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos
Mavacamten for treatment of symptomatic obstructive #hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (LVOT) obstruction. Available pharmacological options for hypertrophic cardiomyopathy are inadequate or poorly tolerated and are not disease-specific. We aimed to assess the efficacy and safety of mavacamten, a first-in-class cardiac myosin inhibitor, in symptomatic… Continue reading Mavacamten for treatment of symptomatic obstructive #hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Association of New-Onset Atrial #Fibrillation After Noncardiac #Surgery With Subsequent #Stroke and Transient Ischemic Attack
Outcomes of postoperative atrial fibrillation (AF) after noncardiac surgery are not well defined.. ..The median age of the 452 matched patients was 75 years (IQR, 67-82 years) and 51.8% of patients were men. Patients with postoperative AF had significantly higher CHA2DS2-VASc scores than those in the no AF group (median, 4 [IQR, 2-5] vs 3… Continue reading Association of New-Onset Atrial #Fibrillation After Noncardiac #Surgery With Subsequent #Stroke and Transient Ischemic Attack
#Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has not been well studied.. ..A total of 331 patients were assigned to receive aspirin alone and 334 were assigned to receive aspirin plus… Continue reading #Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
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