Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index

Recent genome-wide association studies corroborate classical research on developmental programming indicating that obesity is primarily a neurodevelopmental disease strongly influenced by nutrition during critical ontogenic windows. Epigenetic mechanisms regulate neurodevelopment; however, little is known about their role in establishing and maintaining the brain’s energy balance circuitry. We generated neuron and glia methylomes and transcriptomes from …

Continue reading Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index

Timing of #chocolate intake affects hunger, substrate oxidation, and #microbiota: A randomized controlled trial

Eating chocolate in the morning or in the evening/at night, may differentially affect energy balance and impact body weight due to changes in energy intake, substrate oxidation, microbiota (composition/function), and circadian-related variables. In a randomized controlled trial, postmenopausal females (n = 19) had 100 g of chocolate in the morning (MC), in the evening/at night …

Continue reading Timing of #chocolate intake affects hunger, substrate oxidation, and #microbiota: A randomized controlled trial

Associations between #body-mass index and #COVID-19 severity in 6Β·9 million people in England: a prospective, community-based, cohort study

Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We …

Continue reading Associations between #body-mass index and #COVID-19 severity in 6Β·9 million people in England: a prospective, community-based, cohort study

Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK

Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified. MethodsThis population-based cohort study used routine UK primary care electronic health data linked to secondary care and …

Continue reading Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK

Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at …

Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women