Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences–National … Continue reading Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study

Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were underweight had an increased risk of dementia (hazard ratio [HR] … Continue reading Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study

Association of Healthy #Lifestyle With Years Lived Without Major Chronic Diseases

..Four baseline lifestyle factors (smoking, body mass index, physical activity, and alcohol consumption) were each allocated a score based on risk status: optimal (2 points), intermediate (1 point), or poor (0 points) resulting in an aggregated lifestyle score ranging from 0 (worst) to 8 (best). Sixteen lifestyle profiles were constructed from combinations of these risk factors. Main Outcomes and Measures The number of years between … Continue reading Association of Healthy #Lifestyle With Years Lived Without Major Chronic Diseases

Joint Effects of #Body Mass Index and Waist Circumference on the Incidence of #Hypertension in a Community-Based Chinese Population

.. During 2.3 years of follow-up, 19.1% (n = 97) of the men and 13.6% (n = 158) of the women developed incident hypertension. The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for obesity (BMI ≥30) were 3.49 (1.59–7.66) and 2.60 (1.48–4.55) for men and women, respectively. A 1-point increase in BMI was associated with 8% (OR = 1.08, 95% CI: 1.00–1.17) and 10% … Continue reading Joint Effects of #Body Mass Index and Waist Circumference on the Incidence of #Hypertension in a Community-Based Chinese Population

#Periodontitis increases the risk of respiratory disease mortality in older patients

Evidence for an association between periodontitis and respiratory disease in the older patients is limited.. ..We found that periodontitis was associated with total respiratory disease mortality. Compared with healthy participants, the hazards ratio and 95% confidence interval for total respiratory disease mortality in patients with severe periodontitis was 2.72(1.04,7.11) after adjusting for relevant confounding variables. With increasing severity of periodontitis, risks for chronic obstructive pulmonary … Continue reading #Periodontitis increases the risk of respiratory disease mortality in older patients

Total #Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With #Cardiometabolic Risk Biomarkers

Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences.. ..Hispanic women sat, on average, 50.3 minutes less/day than non‐Hispanic women (P<0.001) and had shorter (3.6 minutes less, P=0.02) mean sitting bout duration. Among all women, longer total sitting time was deleteriously … Continue reading Total #Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With #Cardiometabolic Risk Biomarkers

Body #mass index, #diabetes, and the risk of #Parkinson’s disease

..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93) in the obese group and (adjusted hazard ratio: 0.77; 95% … Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease

#Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study

Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions.. ..In participants who initiated medication use, body mass index increased more (difference in change 0.19; 95% CI, 0.16–0.22) and physical activity declined (−0.09 metabolic equivalent of task hour/day; 95% CI, −0.16 to −0.02) compared with noninitiators. The likelihood of becoming obese (odds ratio: 1.82; 95% CI, 1.63–2.03) and physically … Continue reading #Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study

#Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

The timing of food intake has been associated with obesity and adverse metabolic outcomes, independently of the amount or content of food intake and activity level. However, the impact of the variability in the timing of food intake between weekends and weekdays on BMI (body mass index) remains unexplored. To address that, we propose to study a marker of the variability of meal timing on … Continue reading #Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study

People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases.. schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD) body mass index (BMI) ..Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD … Continue reading Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders A Genome-wide Association Study

Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

Body-mass index (#BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity.. ..We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI … Continue reading Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

#Exercise capacity and #body mass index – important predictors of change in resting #heart rate

Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly predict them. Change in RHR over time (∆RHR) has been found to be a potential predictor of mortality.. In this prospective study, RHR and ∆RHR were evaluated at … Continue reading #Exercise capacity and #body mass index – important predictors of change in resting #heart rate