Obstructive sleep apnoea and 12-month weight loss in adults with class 3 obesity attending a multidisciplinary weight management program

Although there is a strong association between obesity and obstructive sleep apnoea (OSA), the effects of OSA and CPAP therapy on weight loss are less well known. The aim of this study in adults with class 3 obesity attending a multidisciplinary weight management program was to assess the relationship between OSA and CPAP usage, and …

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Fecal #microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits #sleep disturbances in naïve mice

Obstructive sleep apnea (OSA) is a chronic prevalent condition characterized by intermittent hypoxia (IH) and sleep fragmentation (SF). Evidence suggests that OSA can alter the gut microbiome (GM) diversity and composition that may then promote the occurrence of some of the OSA-associated morbidities. However, it is unclear whether perturbations in the GM caused by IH …

Continue reading Fecal #microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits #sleep disturbances in naïve mice

Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis

Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one’s quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in …

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The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial

Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle control during sleep. The noradrenergic agent reboxetine combined with the anti-muscarinic hyoscine butylbromide has recently been shown to improve upper airway function during sleep in healthy individuals. However, whether these findings translate to the clinically relevant …

Continue reading The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial

Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage

To determine whether obstructive sleep apnea (OSA) is associated with intracerebral hemorrhage (ICH) risk, we assessed premorbid OSA exposure of patients with nontraumatic ICH and matched controls. Methods: Ethnic/Racial Variations of Intracerebral Hemorrhage is a multicenter, case-control study evaluating risk factors for ICH that recruited 3000 cases with ICH and 3000 controls. OSA status was …

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