Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy

β-Blockers are important drugs in the treatment of cardiovascular diseases. They are suspected of inducing various psychiatric adverse events (PAEs), particularly depression, affecting cardiovascular morbidity and mortality. We performed a systematic search for double-blind, randomized controlled trials investigating β-blockers to analyze the risk of PAEs or withdrawal of therapy due to PAEs. We extracted the frequencies of PAEs and rates of withdrawals and reviewed them … Continue reading Do #β-Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy

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Nocturnal #Arrhythmias and Heart‐Rate Swings in Patients With Obstructive Sleep #Apnea Syndrome Treated With Beta Blockers

The higher cardiovascular variability and the increased prevalence of arrhythmias in patients with obstructive sleep apneas may contribute to their higher rate of fatal events during sleep. In this regard, the use of beta blockers (BB) is debated because they may induce bradyarrhythmias and alter the pattern of heart rate changes induced by apneas. Thus, the aim of our study is to quantify peri‐apneic heart‐rate … Continue reading Nocturnal #Arrhythmias and Heart‐Rate Swings in Patients With Obstructive Sleep #Apnea Syndrome Treated With Beta Blockers

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Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action

Flushing and erythema are frequent skin symptoms in rosacea. Because their adequate treatment remains a clinical challenge, new treatment options are explored, such as oral β-blockers.. ..Nine studies evaluating the use of carvedilol, propranolol, nadolol, and β-blockers in general were included. Articles studying carvedilol and propranolol showed a large reduction of erythema and flushing during treatment with a rapid onset of symptom control. Bradycardia and … Continue reading Use of #beta-blockers for #rosacea-associated facial erythema and flushing: A systematic review and update on proposed mode of action

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Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis

The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible beneficial effect of beta-blocker on overall survival in lung cancer … Continue reading Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis

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Clinical Outcomes With #Beta-Blocker Use in Patients With Recent History of Myocardial #Infarction

It is uncertain whether beta-blockers (BBs) are beneficial in contemporary stable patients with prior myocardial infarction (MI). Therefore, we sought to examine the effectiveness of BB use in this population.. ..We included 33,811 patients with prior MI, of whom 21,440 (63.4%) were dispensed a BB. The median age was 78 years, and 56% were male. There was no difference in the 1-year hazard of death/hospitalization … Continue reading Clinical Outcomes With #Beta-Blocker Use in Patients With Recent History of Myocardial #Infarction

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