Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (LVOT) obstruction. Available pharmacological options for hypertrophic cardiomyopathy are inadequate or poorly tolerated and are not disease-specific. We aimed to assess the efficacy and safety of mavacamten, a first-in-class cardiac myosin inhibitor, in symptomatic… Continue reading Mavacamten for treatment of symptomatic obstructive #hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Category: Cardiology
Association of New-Onset Atrial #Fibrillation After Noncardiac #Surgery With Subsequent #Stroke and Transient Ischemic Attack
Outcomes of postoperative atrial fibrillation (AF) after noncardiac surgery are not well defined.. ..The median age of the 452 matched patients was 75 years (IQR, 67-82 years) and 51.8% of patients were men. Patients with postoperative AF had significantly higher CHA2DS2-VASc scores than those in the no AF group (median, 4 [IQR, 2-5] vs 3… Continue reading Association of New-Onset Atrial #Fibrillation After Noncardiac #Surgery With Subsequent #Stroke and Transient Ischemic Attack
#Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
The effect of single as compared with dual antiplatelet treatment on bleeding and thromboembolic events after transcatheter aortic-valve implantation (TAVI) in patients who do not have an indication for long-term anticoagulation has not been well studied.. ..A total of 331 patients were assigned to receive aspirin alone and 334 were assigned to receive aspirin plus… Continue reading #Aspirin with or without #Clopidogrel after Transcatheter Aortic- #Valve Implantation
Meta-analysis of Effectiveness of #Statins in Patients with Severe #COVID-19
..Our Pubmed search yielded 274 potential studies. After deduplication and application of the eligibility criteria, four studies with a total of 8,990 COVID-19 patients were included for meta-analysis. Except for Yan et al. which is of moderate quality (5/9), other studies are of good quality (at least 7/9). Study characteristics are provided in Table 1.… Continue reading Meta-analysis of Effectiveness of #Statins in Patients with Severe #COVID-19
The change in #kidney function was associated with #carotid artery plaque in a community-based population: a cohort study
We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6±11.6 years) free of chronic kidney diseases were enrolled. The change in… Continue reading The change in #kidney function was associated with #carotid artery plaque in a community-based population: a cohort study
Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study
..Results Across the three databases, 310 840 propensity score matched adults who started canagliflozin or a GLP-1 agonist were identified. The hazard ratio and rate difference per 1000 person years for amputation in adults receiving canagliflozin compared with a GLP-1 agonist for each group was: group 1, hazard ratio 1.09 (95% confidence interval 0.83 to 1.43),… Continue reading Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study
Association Between the Gut #Microbiota and Blood #Pressure in a Population Cohort of 6953 Individuals
Several small‐scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable‐adjusted association between gut metagenome and BP in a large, representative, well‐phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations… Continue reading Association Between the Gut #Microbiota and Blood #Pressure in a Population Cohort of 6953 Individuals
Association of acute myocardial #infarction with #influenza: A nationwide observational study
Influenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration.. Weekly laboratory-confirmed influenza case reports were obtained from the Public Health Agency of Sweden from 2009 to 2016 and merged with… Continue reading Association of acute myocardial #infarction with #influenza: A nationwide observational study
Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis
Results have been mixed and uncertainty still remains regarding the impact of statin adherence on premature deaths. Thus, we investigated the association between statin adherence and risks of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients in South Korea.. We used data from the National Health Insurance Service (NHIS) National Sample Cohort for the years… Continue reading Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis
2 Medical News 