Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis

Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous gut bacteria drive immunophenotypic variability in mouse models of human disease remains poorly understood. We performed a large-scale experiment using 579 genetically identical laboratory mice from a single animal facility, designed …

Continue reading Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis

SARS-CoV-2 vaccines: Lights and shadows

Highglights• So far, vaccines to prevent SARS-CoV-2 infection appear as promising approach for curbing the pandemic. • Vaccines for SARS-CoV-2 are being developed using several different platforms. • Some concerns have been raised regarding the safety of SARS-CoV-2 vaccines on the basis of rare adverse reactions, particularly thromboembolic. • The applicability to the real life …

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The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids

The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the current study we explore the functional interactions between the endocannabinoid system and the gut microbiome in …

Continue reading The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids

#EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase …

Continue reading #EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

Interrelationships between small airways dysfunction, neutrophilic #inflammation and exacerbation frequency in #COPD

Small airways disease (SAD) is a key component of COPD and is a main contributing factor to lung function decline.. ..Thirty nine COPD subjects defined as either frequent exacerbators ( ≥ 2 exacerbations per year, n = 17) and infrequent exacerbators (≤1 exacerbation per year, n = 22) underwent Forced Oscillation Technique (R5-R19, AX), multiple …

Continue reading Interrelationships between small airways dysfunction, neutrophilic #inflammation and exacerbation frequency in #COPD