Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who… Continue reading Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecular mechanisms of action. The KCNQ5 voltage-gated potassium channel contributes to vascular smooth muscle tone and neuronal M-current regulation. Methods: We applied electrophysiology, myography, mass spectrometry… Continue reading KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional… Continue reading ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
As an active interface between the host and their diet, the gut microbiota influences host metabolic adaptation; however, the contributions of fungi have been overlooked. Here, we investigate whether variations in gut mycobiome abundance and composition correlate with key features of host metabolism. We obtained animals from four commercial sources in parallel to test if… Continue reading The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used. METHODS We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which… Continue reading A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Low #Zinc Levels at Admission Associates with Poor Clinical Outcomes in #SARS-CoV-2 Infection
Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19)… Continue reading Low #Zinc Levels at Admission Associates with Poor Clinical Outcomes in #SARS-CoV-2 Infection
Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade “B” recommendation).1 In this… Continue reading Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
#Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study
Prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) prevents pneumocystis jirovecii infection in SLE on immunosuppression. Its role in preventing other major infections in immuno suppressed SLE patients is unknown. Methods A non-concurrent cohort study was conducted on patients of SLE fulfilling SLICC and/or ACR 1997 criteria, who received tapering dose of steroid starting with ≥0.5 mg/kg/day of prednisolone or equivalent… Continue reading #Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study
Short-Course #Antimicrobial Therapy for Pediatric Community-Acquired #Pneumonia The SAFER Randomized Clinical Trial
Community-acquired pneumonia (CAP) is a common occurrence in childhood; consequently, evidence-based recommendations for its treatment are required. Objective To determine whether 5 days of high-dose amoxicillin for CAP was associated with noninferior rates of clinical cure compared with 10 days of high-dose amoxicillin. Design, Setting, and Participants The SAFER (Short-Course Antimicrobial Therapy for Pediatric Respiratory… Continue reading Short-Course #Antimicrobial Therapy for Pediatric Community-Acquired #Pneumonia The SAFER Randomized Clinical Trial
2 Medical News 