#Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population

Hydroxychloroquine (HCQ) has been associated with improved survival among patients with systemic lupus erythematosus (SLE) from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. MethodsWe conducted a nested case–control study within an incident SLE cohort from the entire …

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Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus

Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cytokines, chemokines, and costimulatory molecules. Persistent activation of pDCs has been demonstrated in a number of autoimmune diseases. To …

Continue reading Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus

#Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study

Prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) prevents pneumocystis jirovecii infection in SLE on immunosuppression. Its role in preventing other major infections in immuno suppressed SLE patients is unknown. Methods A non-concurrent cohort study was conducted on patients of SLE fulfilling SLICC and/or ACR 1997 criteria, who received tapering dose of steroid starting with β‰₯0.5 mg/kg/day of prednisolone or equivalent …

Continue reading #Cotrimoxazole prophylaxis prevents major infective episodes in patients with systemic #lupus erythematosus on immunosuppressants: A non-concurrent cohort study

Anti-neutrophil properties of natural #gingerols in models of #lupus

Ginger is known to have anti-inflammatory and anti-oxidative effects, and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report anti-neutrophil properties of 6-gingerol, the most abundant bioactive compound of ginger root, in models of lupus and antiphospholipid syndrome (APS). Specifically, we demonstrate that 6-gingerol attenuates neutrophil …

Continue reading Anti-neutrophil properties of natural #gingerols in models of #lupus