Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic review and individual patient data meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Ovid Medline, Ovid Embase, EBSCO CINAHL Plus, and Web of Science. Eligibility criteria for study selection Randomised controlled trials … Continue reading Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

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Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled … Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

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Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity

In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade โ€œBโ€ recommendation).1 In this issue of JAMA, the USPSTF updates this recommendation, proposing 2 … Continue reading Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity

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Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection

Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass spectrometry (TD-GCโ€“MS) to obtain the metabolic information from volatile organic … Continue reading Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection

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#Cancer Statistics, 2021

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on populationโ€based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by … Continue reading #Cancer Statistics, 2021

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Distinct developmental pathways from blood #monocytes generate human #lung macrophage diversity

The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect the development of lung macrophages from human hematopoiesis in vivo. Human CD34+ hematopoietic stem and progenitor cells (HSPCs) generated three macrophage populations, occupying separate anatomical niches in the lung. Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical … Continue reading Distinct developmental pathways from blood #monocytes generate human #lung macrophage diversity

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Chest x-ray findings and temporal #lung changes in patients with #COVID-19 pneumonia

Chest CT scan and chest x-rays show characteristic radiographic findings in patients with COVID-19 pneumonia. Chest x-ray can be used in diagnosis and follow up in patients with COVID-19 pneumonia. The study aims at describing the chest x-ray findings and temporal radiographic changes in COVID-19 patients.. ..A total of 88 patients (50 (56.8%) females and 38 (43.2%) males) were admitted to the hospital with confirmed … Continue reading Chest x-ray findings and temporal #lung changes in patients with #COVID-19 pneumonia

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Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis

The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible beneficial effect of beta-blocker on overall survival in lung cancer … Continue reading Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis

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Electronic-#cigarette smoke induces #lung adenocarcinoma and #bladder urothelial hyperplasia in mice

Electronic-cigarettes (E-cigs) are marketed as a safe alternative to tobacco to deliver the stimulant nicotine, and their use is gaining in popularity, particularly among the younger population. We recently showed that mice exposed to short-term (12 wk) E-cig smoke (ECS) sustained extensive DNA damage in lungs, heart, and bladder mucosa and diminished DNA repair in lungs.. ..We found that mice exposed to ECS for 54 … Continue reading Electronic-#cigarette smoke induces #lung adenocarcinoma and #bladder urothelial hyperplasia in mice

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