Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial

Postpartum depression (PPD) is one of the most common medicalcomplications during and after pregnancy, negatively affecting both mother and child.OBJECTIVE To demonstrate the efficacy and safety of zuranolone, a neuroactive steroidγ-aminobutyric acid receptor–positive allosteric modulator, in PPD. DESIGN, SETTING, AND PARTICIPANTS This phase 3, double-blind, randomized, outpatient,placebo-controlled clinical trial was conducted between January 2017 and … Continue reading Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial

The associations between prenatal #cannabis use disorder and neonatal outcomes

Background and AimsCannabis use disorder (CUD) during pregnancy has increased dramatically in the United States (US). This study examined the associations between prenatal CUD and adverse neonatal outcomes and heterogeneities in the associations by mothers’ tobacco use status and race/ethnicity. DesignPopulation-based, retrospective cohort study. SettingCalifornia, USA. ParticipantsA total of 4.83 million mothers who delivered a … Continue reading The associations between prenatal #cannabis use disorder and neonatal outcomes