Objective: This study aimed to evaluate how insulin sensitivity and secretion defects during mid-pregnancy influence the development of early postpartum glucose intolerance in women diagnosed with gestational diabetes mellitus (GDM).Methods: A total of 1,256 pregnant women diagnosed with GDM between October 2005 and March 2023 were enrolled. Participants were categorized into four groups: GDM-normal, GDM-secretion… Continue reading Effect of insulin sensitivity and secretion defects at mid-pregnancy on early postpartum glucose intolerance in women with gestational diabetes mellitus
Category: Gynaecology
Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity
Background: An anticipated menopause is a disquieting health problem; its association with autoimmune disorders has been reported. However, data about the presence of premature ovarian insufficiency (POI) and early menopause (EM) framed in thyroid-related poly-autoimmunity are rather scanty. In this view, we described the presence of a precocious menopause in a large cohort of women… Continue reading Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity
Artificial intelligence-assisted histopathological diagnosis of endocervical gastric-type adenocarcinoma: a multicenter model development and validation study
Endocervical gastric-type adenocarcinoma (GAS) is one of the most aggressive subtypes of cervical cancer and is frequently underdiagnosed due to morphological ambiguity, leading to delayed diagnosis. Despite the availability of molecular and genomic assays, their high cost, complexity, and limited reproducibility restrict clinical use. This study therefore proposes a highly sensitive artificial intelligence (AI)-assisted diagnostic… Continue reading Artificial intelligence-assisted histopathological diagnosis of endocervical gastric-type adenocarcinoma: a multicenter model development and validation study
Ovarian Hyperstimulation Syndrome: An Unusual Cause of Abdominal Pain Presenting to the Emergency Department
The use of assisted reproductive technologies (ART), such as in vitro fertilization (IVF), is steadily increasing. Ovarian hyperstimulation syndrome (OHSS) is a rare but potentially serious complication arising from controlled ovarian hyperstimulation (COH), a critical component of ART. OHSS may vary in severity and usually causes abdominal pain, nausea, vomiting, diarrhea, and dyspnea, which are… Continue reading Ovarian Hyperstimulation Syndrome: An Unusual Cause of Abdominal Pain Presenting to the Emergency Department
Toward Precision Aspirin Prophylaxis: Optimal Aspirin Dosing For Prevention of Preeclampsia
Purpose of review: To review contemporary evidence regarding optimal aspirin dosing for prevention of preeclampsia, focusing on dose-response relationships, timing of initiation, and phenotype-specific prophylaxis.Recent findings: Recent trials and meta-analyses have produced conflicting findings regarding whether higher-dose aspirin (100-162 mg daily) provides greater protection against preeclampsia than conventional 75-81 mg regimens. Benefit appears greatest in… Continue reading Toward Precision Aspirin Prophylaxis: Optimal Aspirin Dosing For Prevention of Preeclampsia
Maternal Bleeding Outcomes in Pregnant Women With Immune Thrombocytopenia (ITP): A National Database Study
Objective: Immune thrombocytopenic purpura (ITP) is a hematological disorder commonly affecting women of reproductive age, but limited studies explore the maternal morbidity in pregnant patients with ITP. This study aimed to investigate whether pregnant women with ITP are at higher risk of bleeding complications during and after delivery.Methods: We analyzed the National Inpatient Sample (NIS)… Continue reading Maternal Bleeding Outcomes in Pregnant Women With Immune Thrombocytopenia (ITP): A National Database Study
Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
Polycystic ovary syndrome (#PCOS ) and its underlying features remain poorly understood. In this genetic study (n = 544,513), we expand the number of genetic loci from 16 to 29, and additionally identify 31 associated plasma proteins. Many risk-increasing loci were associated with later age at menopause, underscoring the reproductive longevity related to an increased… Continue reading Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
Exploring White Matter Microstructural Abnormalities Using MRI in Women With Premenstrual Dysphoric Disorder via Brain Connectome
Background: The neurostructural underpinnings of #premenstrual dysphoric disorder (PMDD), particularly integrated white matter and network alteration, remain unclear.Purpose: To identify a core structural network in PMDD by integrating multiple diffusion tensor imaging (DTI)-derived metrics and to develop a predictive model.Study type: Prospective case-control study.Subjects: Forty-two PMDD patients (age: 23.86 ± 1.32 years), diagnosed according to… Continue reading Exploring White Matter Microstructural Abnormalities Using MRI in Women With Premenstrual Dysphoric Disorder via Brain Connectome
Efficacy and Safety of Acupoint Catgut Embedding for Obesity Associated with Polycystic Ovary Syndrome: A Qualitative and Quantitative Analysis
AbstractAim: #Obesity is common in women with polycystic ovary syndrome (PCOS) and can exacerbate #PCOS symptoms. Although Acupoint catgut embedding (ACE) is frequently used to treat the clinical symptoms of simple obesity, it is unclear how it will affect obesity associated with PCOS. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs)… Continue reading Efficacy and Safety of Acupoint Catgut Embedding for Obesity Associated with Polycystic Ovary Syndrome: A Qualitative and Quantitative Analysis
