Association of spontaneous #abortion with all cause and cause specific premature #mortality: prospective cohort study

To investigate the association of spontaneous abortion with the risk of all cause and cause specific premature mortality (death before the age of 70). Design Prospective cohort study. Setting The Nurses’ Health Study II (1993-2017), United States. Participants 101 681 ever gravid female nurses participating in the Nurses’ Health Study II. Main outcomes measures Lifetime occurrence of spontaneous abortion in pregnancies lasting less than 6 months, … Continue reading Association of spontaneous #abortion with all cause and cause specific premature #mortality: prospective cohort study

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OR10-1 – Efficacy of High-Intensity Intermittent #Training for Improving Cardio-Metabolic Health in Women With #Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with significant metabolic and reproductive manifestations, carrying a major health and economic burden. Consistent improvements in clinical outcomes have been reported as a result of exercise training, but shortfalls with exercise prescription are evident. Research suggests that high-intensity intermittent training (HIIT) is feasible, well tolerated and enjoyable for people with or at risk of chronic … Continue reading OR10-1 – Efficacy of High-Intensity Intermittent #Training for Improving Cardio-Metabolic Health in Women With #Polycystic Ovary Syndrome

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Hormone therapy as a possible solution for post #menopausal women with #nocturia results of a pilot trial

To observe the impact of different hormonal treatment options on nocturia, its causative factors and bother in postmenopausal women. Methods: This prospective study recruited 245 postmenopausal women and divided them into four treatment groups based on patient’s choice: Estrogen + Progesterone (E+P), Estrogen-only in patients with a prior hysterectomy, tissue-selective estrogen complex (TSEC) and no treatment. Nocturia and its causative factors were observed using two … Continue reading Hormone therapy as a possible solution for post #menopausal women with #nocturia results of a pilot trial

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A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening

Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used. METHODS We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which the blood glucose level was obtained after the oral administration … Continue reading A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening

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Association between #obesity with pattern and length of #menstrual cycle: The role of metabolic and hormonal markers

To evaluate in a sample of Chilean adult women, the association between adiposity markers with pattern and length of the menstrual cycle, assessing the influence of metabolic markers and hormones in this relationship. Study design We conducted a cross-sectional study involving 401 premenopausal women belonging to the DERCAM study (Determinants of Breast Cancer Risk) from Santiago, Chile. The menstrual cycle pattern was defined as regular … Continue reading Association between #obesity with pattern and length of #menstrual cycle: The role of metabolic and hormonal markers

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Risk‐adapted starting age of #breast cancer screening in women with a family history of #ovarian or other cancers: A nationwide cohort study

There is a lack of evidence‐based recommendations for the age at which women with a family history of cancers other than breast cancer should start breast cancer screening. METHODS Using Swedish family cancer data sets, the authors conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931 (follow‐up, 1958‐2015). Accounting for calendar time, they calculated the relative risk of breast cancer for women … Continue reading Risk‐adapted starting age of #breast cancer screening in women with a family history of #ovarian or other cancers: A nationwide cohort study

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Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after … Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy

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#Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery

…A total of 5522 (17%) children were born to mothers exposed to antibiotics during pregnancy. In adjusted analyses, children born to exposed mothers had higher odds of asthma (OR 1.14, 95% CI 1.05 to 1.24). There was no association with antibiotic exposure in the first trimester (OR 1.02, 95% CI 0.83 to 1.26), but higher odds were observed for antibiotic exposure in the second to … Continue reading #Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery

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Incorporating Baseline Breast #Density When Screening Women at Average Risk for #Breast Cancer

..Intervention: No screening; biennial or triennial mammography from age 50 to 75 years; annual mammography from age 50 to 75 years for women with dense breasts at age 50 years and biennial or triennial mammography from age 50 to 75 years for those without dense breasts at age 50 years; and annual mammography at age 40 to 75 years for women with dense breasts at … Continue reading Incorporating Baseline Breast #Density When Screening Women at Average Risk for #Breast Cancer

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#Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies

Epidemiologic evidence regarding association of ovarian cancer risk with blood lipid level and hyperlipidemia is inconsistent. We aimed to synthesize available epidemiologic studies to disentangle associations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and hyperlipidemia with ovarian cancer risk. We searched PubMed, EMBASE, and Web of Science for eligible studies. A random-effects model was applied for synthesis. Heterogeneity was evaluated by … Continue reading #Ovarian cancer risk in relation to blood #lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies

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Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement

..After a literature review of the risk of ipsilateral and contralateral breast cancer events among breast cancer survivors and the harms and benefits associated with mammography, a multidisciplinary expert panel was convened to develop consensus guidelines on surveillance mammography for breast cancer survivors 75 years or older. Using an iterative consensus-based approach, input from clinician focus groups, and critical review by the International Society for … Continue reading Individualizing Surveillance #Mammography for Older Patients After Treatment for Early-Stage #Breast Cancer Multidisciplinary Expert Panel and International Society of Geriatric Oncology Consensus Statement

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2021 The Effect of Preconception-Initiated Low-Dose #Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, #Pregnancy Loss, and Live Birth

A previous large randomized trial indicated that preconception-initiated low-dose aspirin (LDA) therapy did not have a positive effect on pregnancy outcomes. However, this trial was subject to nonadherence, which was not taken into account by the intention-to-treat approach.. ..Relative to placebo, adhering to LDA for 5 of 7 days per week led to 8 more hCG-detected pregnancies (95% CI, 4.64 to 10.96 pregnancies), 15 more … Continue reading 2021 The Effect of Preconception-Initiated Low-Dose #Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, #Pregnancy Loss, and Live Birth

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