Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early AdolescenceLongitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study

Dramatic increases in cannabis use during pregnancy are alarming because of evidence that prenatal exposure may be associated with a host of adverse outcomes. We previously found that prenatal cannabis exposure (PCE) following maternal knowledge of pregnancy is associated with increased psychopathology during middle childhood using baseline data from the Adolescent Brain Cognitive Development (ABCD) study.Here, …

Continue reading Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early AdolescenceLongitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study

Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study

AbstractBackground:Prior research suggests that women with endometriosis are at greater risk of coronary heart disease. Therefore, our objective was to prospectively investigate the association between laparoscopically confirmed endometriosis and risk of incident stroke during 28 years of follow-up.Methods:Participants in the NHSII cohort study (Nurses’ Health Study II) were followed from 1989 when they were between …

Continue reading Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study

Trends, Predictors, and Outcomes of Cardiovascular Complications Associated With Polycystic Ovary Syndrome During Delivery Hospitalizations: A National Inpatient Sample Analysis (2002–2019)

BackgroundWomen with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy‐associated complications. However, data on peripartum cardiovascular complications remain limited. Hence, we investigated trends, outcomes, and predictors of cardiovascular complications associated with PCOS diagnosis during delivery hospitalizations in the United States.Methods and ResultsWe used data from the National Inpatient Sample (2002–2019). International Classification of …

Continue reading Trends, Predictors, and Outcomes of Cardiovascular Complications Associated With Polycystic Ovary Syndrome During Delivery Hospitalizations: A National Inpatient Sample Analysis (2002–2019)

Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

BackgroundCoffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee consumption and miscarriage, stillbirth, birthweight, gestational age and pre-term birth using Mendelian randomization (MR). MethodsA two-sample MR study was performed using summary results data from a genome-wide association …

Continue reading Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study

Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype. …

Continue reading Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study