Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

BackgroundCoffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee consumption and miscarriage, stillbirth, birthweight, gestational age and pre-term birth using Mendelian randomization (MR). MethodsA two-sample MR study was performed using summary results data from a genome-wide association …

Continue reading Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth

Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study

Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype. …

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MP38-16 IS IT TIME FOR FPMRS TO PRESCRIBE VIBRATORS?

Only recently, the stigma of women using vibrators for sexual pleasure has started to fade; however, it still remains a societal taboo and is surrounded with anxiety despite a variety of potential health benefits from its use. Due to the sensitive nature of the conditions Female Pelvic Medicine and Reconstructive Surgery (FPMRS) specialists treat, they …

Continue reading MP38-16 IS IT TIME FOR FPMRS TO PRESCRIBE VIBRATORS?

Sodium accumulation in breast cancer predicts malignancy and treatment response

BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of …

Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response

Efficacy of Single-Dose Human Papillomavirus Vaccination among Young African Women

BACKGROUNDSingle-dose human papillomavirus (HPV) vaccination, if efficacious, would be tremendously advantageous, simplifying implementation and decreasing costs. METHODSWe performed a randomized, multicenter, double-blind, controlled trial of single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11 infection) or bivalent (HPV 16/18 infection) HPV vaccination compared with meningococcal vaccination among Kenyan women 15 to 20 years of age. Enrollment and 6-monthly cervical swabs …

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