Background: Systemic lupus erythematosus (SLE) is an autoimmune disease driven by immune dysregulation. Parabens, commonly used preservatives, are potential environmental factors that may influence immune function and contribute to autoimmune diseases like SLE, although the underlying mechanisms remain unclear.Methods: A network toxicology approach was used to investigate potential associations between parabens and SLE-related genes. Paraben… Continue reading Parabens exposure in systemic lupus erythematosus: insights from network toxicology and molecular docking
Category: Rheumatology
Targeted Treatment for Hyperuricemia: The Drug Pipeline
Gout is the most prevalent inflammatory arthritis worldwide and disproportionately affects older adults, who frequently have comorbid conditions such as chronic kidney disease and cardiovascular disease that lead to polypharmacy and complicate both urate-lowering therapy (ULT) and management of acute flares. Although treat-to-target ULT (lowering and maintaining serum uric acid levels below 6 mg/dL) remains… Continue reading Targeted Treatment for Hyperuricemia: The Drug Pipeline
Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Background: Rheumatoid arthritis (RA)-related physical limitations often hinder sustained physical activity and weight management, thereby amplifying cardiovascular risk through adverse metabolic profiles and chronic inflammation. We aimed to assess the effectiveness of semaglutide on the risk of incident major adverse cardiovascular and cerebrovascular events (MACCE) in obese adults with type 2 diabetes mellitus (T2DM) and… Continue reading Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
The Effects of Disease-Modifying Anti-Rheumatic Drugs on Total Hip #Arthroplasty Outcomes in Patients Who Have Inflammatory Arthropathies
Introduction: Disease-modifying anti-rheumatic drugs (#DMARDs ) are essential in managing inflammatory arthritides such as #rheumatoid arthritis (RA), psoriatic #arthritis (PsA), and juvenile idiopathic arthritis (JIA). As total hip arthroplasty (THA) and DMARD use become more common, it is unclear how DMARD use affects outcomes in this population. This study compared complications and implant survivorship after… Continue reading The Effects of Disease-Modifying Anti-Rheumatic Drugs on Total Hip #Arthroplasty Outcomes in Patients Who Have Inflammatory Arthropathies
Cough as a clinical manifestation of giant cell arteritis
Objectives: #Cough is an underrecognized and atypical manifestation of giant cell #arteritis (GCA), which may lead to diagnostic delay. Literature on cough in GCA is limited and lacks comprehensive data on clinical relevance. The aim of this study was to assess the frequency of cough at diagnosis in GCA patients and to compare clinical characteristics… Continue reading Cough as a clinical manifestation of giant cell arteritis
Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention in at-risk individuals could prevent or delay future tissue damage; however, the immunobiology of this stage is unclear. Using integrative multiomics,… Continue reading Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Objectives This work aimed to resolve the conflicting reports on Prevotellaceae abundance in the development of rheumatoid arthritis (RA) and to observe structural, functional and temporal changes in the gut microbiome in RA progressors versus non-progressors.Methods Individuals at risk of RA were defined by the presence of anticyclic citrullinated protein (anti-CCP) antibodies and new musculoskeletal… Continue reading Dynamics of the gut #microbiome in individuals at risk of #rheumatoid arthritis: a cross-sectional and longitudinal observational study
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot… Continue reading Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
#Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.MethodsWe enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food… Continue reading #Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival
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