HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes … Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
Category: Rheumatology
Hydroxychloroquine (HCQ) has been associated with improved survival among patients with systemic lupus erythematosus (SLE) from tertiary referral centers. We aimed to determine the potential impact of HCQ use on the risk of mortality among SLE patients in the general population. MethodsWe conducted a nested case–control study within an incident SLE cohort from the entire … Continue reading #Hydroxychloroquine and Mortality Among Patients With Systemic #Lupus Erythematosus in the General Population
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH) … Continue reading Auto-immune #hepatitis following #COVID vaccination
To establish the prevalence of nonradiographic sacroiliitis within a real-life sample of patients with psoriatic arthritis (PsA), using pelvic radiographs and magnetic resonance imaging (MRI) of sacroiliac joints (SIJs). Methods. This cross-sectional study included 107 consecutive adults with PsA (Classification Criteria for Psoriatic Arthritis criteria). Participants completed clinical and laboratory evaluation, pelvic radiographs scored for … Continue reading Prevalence of Nonradiographic #Sacroiliitis in Patients With Psoriatic #Arthritis: A Real-life Observational Study
