Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette smoking, are poorly understood.. ..Overall, 473 cases were matched with … Continue reading Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis

Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis

Patients with rheumatoid arthritis (RA) are at high risk for cardiovascular (CV) mortality, attributed to chronic inflammation coupled with elevated circulatory homocysteine levels. Increasing the serum folate level reduces homocysteine, but the association of serum folate concentration with CV mortality in patients with RA has not been previously examined.. A total of 683 patients with RA (mean [SE] age, 55.9 [1.0] years; 225 [30.2%] men; … Continue reading Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis

Adverse Effects of Low-Dose #Methotrexate: A Randomized Trial

Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis.. Random allocation to LD-MTX (≤20 mg/wk) or placebo. All participants received folic acid, 1 mg/d, 6 days per week.. ..The relative hazards of gastrointestinal (HR, 1.91 [CI, 1.75 to 2.10]), pulmonary (HR, 1.52 [CI, 1.16 to 1.98]), infectious (HR, 1.15 [CI, 1.01 … Continue reading Adverse Effects of Low-Dose #Methotrexate: A Randomized Trial

Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study

The IR of opportunistic infections was highest for PM/DM cases (61.3/1000 person-years, 95% confidence interval [CI] 56.6–66.2), followed by SLE cases (43.1/1000 person-years, 95% CI 41.7–44.5), SSc cases (31.6/1000 person-years, 95% CI 28.3–35.1), RA cases (25.0/1000 person-years, 95% CI 24.4–25.7), and pSS cases (24.1/1000 person-years, 95% CI 23.1–25.2). Multivariable Cox analysis revealed that, relative to SLE, PM/DM was associated with a significantly higher risk of … Continue reading Comparing the burdens of opportunistic #infections among patients with systemic #rheumatic diseases: a nationally representative cohort study