The emergence of the severe acute respiratory syndrome coronavirus 2 pandemic has created an unprecedented healthcare, social, and economic disaster. Wearing of masks and social distancing can significantly decrease transmission and spread, however, due to circumstances such as medical or dental intervention and personal choice these practices have not been universally adopted. Additional strategies are… Continue reading Lowering the transmission and spread of human coronavirus
N,N-dimethyltryptamine compound found in the hallucinogenic #tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of… Continue reading N,N-dimethyltryptamine compound found in the hallucinogenic #tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Evidence that #coronavirus superspreading is #fat-tailed
Superspreaders, infected individuals who result in an outsized number of secondary cases, are believed to underlie a significant fraction of total SARS-CoV-2 transmission. Here, we combine empirical observations of SARS-CoV and SARS-CoV-2 transmission and extreme value statistics to show that the distribution of secondary cases is consistent with being fat-tailed, implying that large superspreading events… Continue reading Evidence that #coronavirus superspreading is #fat-tailed
The effects of acute #work #stress and appraisal on psychobiological stress responses in a group office environment
The high prevalence of office stress and its detrimental health consequences are of concern to individuals, employers and society at large. Laboratory studies investigating office stress have mostly relied on data from participants that were tested individually on abstract tasks. In this study, we examined the effect of psychosocial office stress and work interruptions on… Continue reading The effects of acute #work #stress and appraisal on psychobiological stress responses in a group office environment
Effects of #Psilocybin-Assisted Therapy on Major #Depressive Disorder
Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Recent evidence suggests that 1 or 2 administrations of psilocybin with psychological support produces antidepressant effects in patients with cancer and in those with treatment-resistant depression.. ..Two psilocybin sessions (session 1: 20 mg/70 kg; session 2: 30… Continue reading Effects of #Psilocybin-Assisted Therapy on Major #Depressive Disorder
A Time Frame for Testing Negative for SARS- #COV2 in People with #Obesity
Objective: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. Methods: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered fromthe infection. All diagnoses were given using… Continue reading A Time Frame for Testing Negative for SARS- #COV2 in People with #Obesity
#Delirium In Severe Acute Respiratory Syndrome- #Coronavirus -2 Infection: A Point Of View
Coronavirus disease 2019 was for the first time reported in December 2019 in China, and has since spread throughout the world as a pandemic. In this point of view, we aim to discuss the occurrence of central nervous system symptomatology, and delirium, in patients suffering coronavirus disease 2019. To date, most of the research done… Continue reading #Delirium In Severe Acute Respiratory Syndrome- #Coronavirus -2 Infection: A Point Of View
An Immunomodulatory Therapeutic #Vaccine Targeting Oligomeric #Amyloid-β
Background:Aging is considered the most important risk factor for Alzheimer’s disease (AD). Recent research supports the theory that immunotherapy targeting the “oligomeric” forms of amyloid-β (Aβ) may halt the progression of AD. However, previous clinical trial of the vaccine against Aβ, called AN1792, was suspended due to cases of meningoencephalitis in patients. Objective:To develop a… Continue reading An Immunomodulatory Therapeutic #Vaccine Targeting Oligomeric #Amyloid-β
#SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study
The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. In Singapore, extensive contact tracing by the Ministry of Health for every diagnosed COVID-19 case, and legally enforced quarantine and intensive health surveillance of close contacts provided a rare opportunity to… Continue reading #SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study
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