Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 …

Continue reading Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology

Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not …

Continue reading Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology

A Meta-Analysis on the Global Prevalence, Risk factors and Screening of Coronary #Heart Disease in Non-alcoholic #Fatty Liver Disease

Background and AimsCardiovascular disease remains the leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Studies examining the association of coronary heart disease (CHD) and NAFLD are cofounded by various cardiometabolic factors particularly diabetes and body mass index. Hence, we seek to explore such association by investigating the global prevalence, independent risk …

Continue reading A Meta-Analysis on the Global Prevalence, Risk factors and Screening of Coronary #Heart Disease in Non-alcoholic #Fatty Liver Disease

Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients

The ESC/EACTS myocardial revascularization guidelines recently standardized the definition of patients at high ischemic risk (HIR). However, the ability of ESC/EACTS-HIR criteria to stratify ischemic and bleeding risk in a contemporary real-world East Asian cohort remains unexplored. Methods: A total of 10,167 consecutive patients undergoing PCI from prospective Fuwai PCI Registry (January 2013 to December …

Continue reading Prognostic and Practical Validation of ESC/EACTS High #Ischemic Risk Definition on Long-Term Thrombotic and Bleeding Events in Contemporary #PCI Patients

#Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders

Having a family member with an alcohol use disorder (AUD) may negatively affect a person’s health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DesignCohort study. Cox regression models and co-sibling analyses. SettingSweden. ParticipantsFrom population registers, we selected all parent-offspring pairs in …

Continue reading #Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders