Airbags are considered a crucial safety feature in vehicles, offering significant protection by cushioning the occupants during collisions. During a collision, sudden deceleration or impact within a specified angle relative to the vehicle's longitudinal axis triggers crash sensors throughout the vehicle. These sensors send an electrical signal to the airbag cartridge, which rapidly inflates the… Continue reading Airbag-Related Ocular and Facial Trauma in Unrestrained Pediatric Front-Seat Passengers: A Report of Two Cases
Category: Ophthalmology
Development and validation of a deep learning model to predict visual and anatomical prognosis of anti-VEGF therapy for neovascular age-related macular degeneration (KongMing Study): a prospective, nationwide, multicentre study
Background: The financial burden and the uncertain response of the anti-vascular endothelial growth factor (anti-VEGF) treatment often cause hesitation among patients with neovascular age-related #macular degeneration (nAMD), highlighting the need for a reliable method to predict treatment outcomes. We aimed to develop and validate a deep learning model that can predict the visual and anatomical… Continue reading Development and validation of a deep learning model to predict visual and anatomical prognosis of anti-VEGF therapy for neovascular age-related macular degeneration (KongMing Study): a prospective, nationwide, multicentre study
#Subretinal Photovoltaic Implant to Restore #Vision in Geographic Atrophy Due to AMD
Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in such persons currently exist. The photovoltaic retina implant microarray (PRIMA) system combines a subretinal photovoltaic implant and glasses that project near-infrared light to the implant in… Continue reading #Subretinal Photovoltaic Implant to Restore #Vision in Geographic Atrophy Due to AMD
#Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
INTRODUCTIONInvestigations of retinal biomarkers for #Alzheimer's disease (AD) and AD and related dementias (ADRD), has increased significantly. We examine retinal vascular health in a mouse containing the ADRD risk variant Mthfr677C>T to determine if changes in retina mirror similar changes in cerebrovasculature.METHODSMorphology and function of retinal vasculature and neurons were assessed using in vivo imaging,… Continue reading #Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Smartphones have revolutionized our daily lives, becoming portable pocket computers with easy internet access. India, the second-highest smartphone and internet user, experienced a significant rise in smartphone usage between 2013 and 2024. Prolonged smartphone use, exceeding 20 min at a time, can lead to physical and mental health issues, including psychophysiological disorders. Digital devices and… Continue reading Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Decoding #memory function through naturalistic gaze patterns
#Eye movements are closely linked to encoding and retrieval processes, with changes in viewing behavior reflecting age- and pathology-related memory decline. In the current study, we leveraged this relationship to explore possible gaze-based indicators of memory function. Across two task-free viewing experiments, we investigated changes in naturalistic viewing behavior across five participant groups spanning a… Continue reading Decoding #memory function through naturalistic gaze patterns
Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
Coffee is a popular beverage, and previous cohort studies suggest it may reduce the risk of age-related macular degeneration (AMD). However, confounding factors in these studies necessitate further exploration of causal relationships using advanced methods. We obtained data on coffee consumption from genome-wide association studies (GWAS) and the latest AMD-related GWAS summary data from the… Continue reading Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
#Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in treating diabetes and obesity, yet little is known about the long-term ocular effects of systemic prolonged exposure.Objective To evaluate the risk of developing neovascular age-related macular degeneration (nAMD) associated with the use of GLP-1 RAs in patients with diabetes.Design, Setting, and Participants This population-based,… Continue reading #Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
Highlights• Elevated retinal homocysteine is a pathogenic feature of glaucoma• One-carbon metabolism is dysregulated in glaucoma• Oral B6, B9, B12, and choline is neuroprotective in animal modelsSummaryGlaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine… Continue reading Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
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