SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to constrain viral pathology to the nasopharynx. Which cells SARS-CoV-2 primarily targets and how infection influences the respiratory epithelium remains incompletely understood. We performed scRNA-seq on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, we … Continue reading Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
Category: ENT
AUDIENCE: Consumer, Patient, Health Professional, Pharmacy ISSUE: The FDA is warning that the abuse and misuse of the over-the-counter (OTC) nasal decongestant propylhexedrine can lead to serious harm such as heart and mental health problems. Some of these complications, which include fast or abnormal heart rhythm, high blood pressure, and paranoia, can lead to hospitalization, … Continue reading Benzedrex (#propylhexedrine): Drug Safety Communication – FDA Warns that Abuse and Misuse of the Nasal #Decongestant Causes Serious Harm
Olfactory dysfunction is associated with the transition from normal cognition to dementia in persons without type 2 diabetes. This study aimed to investigate whether olfactory dysfunction could be an early marker of future dementia in older patients with type 2 diabetes. Methods This exploratory study included 151 older Japanese outpatients with type 2 diabetes who … Continue reading #Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
To assess the use of proton pump inhibitors (PPIs) to treat persistent throat symptoms.. ..Random blinded allocation (1:1) to either 30 mg lansoprazole twice daily or matched placebo twice daily for 16 weeks. Main outcome measures Primary outcome was symptomatic response at 16 weeks measured using the total reflux symptom index (RSI) score. Secondary outcomes … Continue reading Use of #proton pump inhibitors to treat persistent #throat symptoms: multicentre, double blind, randomised, placebo controlled trial
