The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase… Continue reading #EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
#Cooking as a Health Behavior: Examining the Role of Cooking Classes in a #Weight Loss Intervention
Americans are cooking fewer meals at home and eating more convenience foods prepared elsewhere. Cooking at home is associated with higher quality diets, while a reduction in cooking may be associated with increases in obesity and risk factors for chronic disease. The aims of this study were to examine cooking as an intervention for weight… Continue reading #Cooking as a Health Behavior: Examining the Role of Cooking Classes in a #Weight Loss Intervention
Vitamin #D metabolites and the gut #microbiome in older men
The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of the interactions between the gut microbiome and vitamin D, we conduct a cross-sectional analysis of 567 older men quantifying serum vitamin D metabolites using LC-MSMS and defining stool sub-Operational Taxonomic Units from16S ribosomal RNA… Continue reading Vitamin #D metabolites and the gut #microbiome in older men
Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
Sleep-related impairment in physicians is an occupational hazard associated with long and sometimes unpredictable work hours and may contribute to burnout and self-reported clinically significant medical error.. ..Of all physicians invited to participate in the survey, 7700 of 19 384 attending physicians (40%) and 3695 of 7257 house staff physicians (51%) completed sleep-related impairment items, including… Continue reading Assessment of Physician #Sleep and Wellness, #Burnout, and Clinically Significant Medical Errors
Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six… Continue reading Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
Antiseizure medications (ASMs) can rarely result in severe, sometimes fatal, cutaneous adverse reactions. To date, few studies have reported on the incidence rates (IRs) of severe cutaneous adverse reactions (SCARs) due to ASM use. This study aimed to determine the IRs of SCAR resulting from the use of seven commonly prescribed ASMs, carbamazepine (CBZ), phenytoin… Continue reading Incidence rates of severe #cutaneous adverse reactions due to anti #seizure medication: A nationwide study using health claims data in Korea
#Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy.. ..The rate of decline in 3MS was significantly… Continue reading #Cognitive decline in older adults with #epilepsy: The Cardiovascular Health Study
Older Adults and the Mental Health Effects of #COVID-19
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate… Continue reading Older Adults and the Mental Health Effects of #COVID-19
Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased… Continue reading Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
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