Sodium accumulation in breast cancer predicts malignancy and treatment response

BackgroundBreast cancer remains a leading cause of death in women and novel imaging biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment-monitoring potential of non-invasive sodium (23Na) MRI in preclinical models of breast cancer. MethodsFemale Rag2−/− Il2rg−/− and Balb/c mice bearing orthotopic breast tumours (MDA-MB-231, EMT6 and 4T1) underwent MRI as part of …

Continue reading Sodium accumulation in breast cancer predicts malignancy and treatment response

Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study

The food industry uses artificial sweeteners in a wide range of foods and beverages as alternatives to added sugars, for which deleterious effects on several chronic diseases are now well established. The safety of these food additives is debated, with conflicting findings regarding their role in the aetiology of various diseases. In particular, their carcinogenicity …

Continue reading Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

MYC's role in promoting tumorigenesis is beyond doubt, but its function in the metastatic process is still controversial. Omomyc is a MYC dominant negative that has shown potent antitumor activity in multiple cancer cell lines and mouse models, regardless of their tissue of origin or driver mutations, by impacting on several of the hallmarks of …

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#Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors

High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term …

Continue reading #Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors

Women who #breastfeed exhibit #cognitive benefits after age 50

AbstractBackground and objectivesWomen who breastfeed may experience long-term benefits for their health in addition to the more widely-appreciated effects on the breastfed child. Breastfeeding may induce long-term effects on biopsychosocial systems implicated in brain health. Also, due to diminished breastfeeding in the post-industrial era, it is important to understand the lifespan implications of breastfeeding for …

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