Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control… Continue reading Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
RANK links #thymic regulatory T cells to fetal loss and gestational #diabetes in pregnancy
Successful pregnancies rely on adaptations within the mother1, including marked changes within the immune system2. It has long been known that the thymus, the central lymphoid organ, changes markedly during pregnancy3. However, the molecular basis and importance of this process remain largely obscure. Here we show that the osteoclast differentiation receptor RANK4,5 couples female sex… Continue reading RANK links #thymic regulatory T cells to fetal loss and gestational #diabetes in pregnancy
#Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Very few studies have explored the patterns of cardiovascular health (CVH) metrics in midlife and late life in relation to risk of dementia. We examined the associations of composite CVH metrics from midlife to late life with risk of incident dementia. This cohort study included 1,449 participants from the Finnish Cardiovascular Risk Factors, Aging, and… Continue reading #Cardiovascular health metrics from mid- to late-life and risk of #dementia: A population-based cohort study in Finland
Characterizing #COVID-19 and #Influenza Illnesses in the Real World via Person-Generated Health Data
The fight against COVID-19 is hindered by similarly presenting viral infections that may confound detection and monitoring. We examined Person-generated Health Data (PGHD), consisting of survey and commercial wearable data from individuals’ everyday lives, for 230 people who reported a COVID-19 diagnosis between 2020-03-30 and 2020-04-27 (N=41 with wearable data). Compared to self-reported diagnosed flu… Continue reading Characterizing #COVID-19 and #Influenza Illnesses in the Real World via Person-Generated Health Data
Identification and Management of #Eating Disorders in Children and #Adolescents
Eating disorders are serious, potentially life-threatening illnesses afflicting individuals through the life span, with a particular impact on both the physical and psychological development of children and adolescents. Because care for children and adolescents with eating disorders can be complex and resources for the treatment of eating disorders are often limited, pediatricians may be called… Continue reading Identification and Management of #Eating Disorders in Children and #Adolescents
The #Coronavirus Is Mutating. What Does That Mean for Us?
By Apoorva Mandavilli - NYT Just as vaccines begin to offer hope for a path out of the pandemic, officials in Britain this past weekend sounded an urgent alarm about what they called a highly contagious new variant of the coronavirus circulating in England. Citing the rapid spread of the virus through London and surrounding… Continue reading The #Coronavirus Is Mutating. What Does That Mean for Us?
The influence of #proton pump inhibitor therapy on the outcome of #infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies
In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD.. Among the five randomised controlled studies, there were 889 and 147 patients on infliximab with and without… Continue reading The influence of #proton pump inhibitor therapy on the outcome of #infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies
#Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients
SARS-CoV-2 infection is associated with hypercoagulability which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in COVID-19 patients and their association with VTE. Methods Hospitalized COVID-19 patients and age- and sex-matched healthy controls were studied. Platelet and leukocyte activation, neutrophil extracellular traps (NETs), and matrix metalloproteinase-9 (MMP-9), a neutrophil-released enzyme, were measured.… Continue reading #Neutrophil more than #platelet activation associates with #thrombotic complications in #COVID-19 patients
#UV-LED disinfection of #Coronavirus: Wavelength effect
UV light-emitting diodes (UV LEDs) are an emerging technology and a UV source for pathogen inactivation, however low UV-LED wavelengths are costly and have low fluence rate. Our results suggest that the sensitivity of human Coronavirus (HCoV-OC43 used as SARS-CoV-2 surrogate) was wavelength dependent with 267 nm ~ 279 nm > 286 nm > 297… Continue reading #UV-LED disinfection of #Coronavirus: Wavelength effect
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