Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. Protein aggregation underlies pathologies including neurodegeneration. Aggregates’ formation is antagonised by molecular chaperones, with cytoplasmic machinery resolving insoluble protein aggregates. However, it is unknown whether an analogous disaggregation system exists in the Endoplasmic Reticulum …

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Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock

Distribution of dietary protein across meals influences muscle hypertrophy•BCAAs are involved in hypertrophic effects of protein feeding distribution•Hypertrophic effects of protein feeding distribution require the muscle clock•Breakfast protein intake is correlated with skeletal muscle functions in older women SummaryThe meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the …

Continue reading Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock

Association of Major Dietary #Protein Sources With All‐Cause and Cause‐Specific #Mortality: Prospective Cohort Study

Dietary recommendations regarding protein intake have been focused on the amount of protein. However, such recommendations without considering specific protein sources may be simplistic and insufficient. Methods and Results We included 102 521 postmenopausal women enrolled in the Women’s Health Initiative between 1993 and 1998, and followed them through February 2017. During 1 876 205 …

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Dietary intake of total, animal, and #plant #proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

..32 prospective cohort studies were included in the systematic review and 31 in the meta-analysis. During the follow-up period of 3.5 to 32 years, 113 039 deaths (16 429‬ from cardiovascular disease and 22 303‬ from cancer) occurred among 715 128 participants. Intake of total protein was associated with a lower risk of all cause mortality (pooled effect size …

Continue reading Dietary intake of total, animal, and #plant #proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies

#Potato Protein Isolate Stimulates #Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women

Skeletal muscle myofibrillar protein synthesis (MPS) increases in response to protein feeding and to resistance exercise (RE), where each stimuli acts synergistically when combined. The efficacy of plant proteins such as potato protein (PP) isolate to stimulate MPS is unknown. We aimed to determine the effects of PP ingestion on daily MPS with and without …

Continue reading #Potato Protein Isolate Stimulates #Muscle Protein Synthesis at Rest and with Resistance Exercise in Young Women