Impaired intestinal epithelial barrier is highly affected in inflammatory bowel disease. Transmembrane collagens connecting the epithelial cells to the extracellular matrix have an important role in epithelial cell homeostasis. Thus, we sought to determine whether the transmembrane type 23 collagen could serve as a surrogate marker for disease activity in patients with Crohn’s disease and… Continue reading Elevated ectodomain of type 23 #collagen is a novel biomarker of the intestinal epithelium to monitor disease activity in #ulcerative colitis and #Crohn’s disease
#Biomarkers, disability and health care demand
Using longitudinal data from a representative UK panel, we focus on a group of apparently healthy individuals with no history of disability or major chronic health condition at baseline. A latent variable structural equation model is used to analyse the predictive role of latent baseline biological health, indicated by a rich set of biomarkers, and… Continue reading #Biomarkers, disability and health care demand
The global epidemiology of #hypertension
Hypertension is the leading cause of cardiovascular disease and premature death worldwide. Owing to the widespread use of antihypertensive medications, global mean blood pressure (BP) has remained constant or has decreased slightly over the past four decades. By contrast, the prevalence of hypertension has increased, especially in low- and middle-income countries (LMICs). Estimates suggest that… Continue reading The global epidemiology of #hypertension
#Dapagliflozin and the Incidence of Type 2 #Diabetes in Patients With #Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF
The sodium–glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) trial. This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial RESEARCH DESIGN AND METHODS… Continue reading #Dapagliflozin and the Incidence of Type 2 #Diabetes in Patients With #Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF
Prognostic value of #electrocardiographic abnormalities in adults from the Brazilian longitudinal study of adults’ health
Cardiovascular diseases (CVDs) are highly preventable non-communicable diseases. ECG is a potential tool for risk stratification with respect to CVD. Our aim was to evaluate ECG’s role in all-cause and cardiovascular mortality prediction. Methods Participants from the Brazilian Longitudinal Study of Adult Health, free of known CVD at baseline were included. A 12-lead ECG was… Continue reading Prognostic value of #electrocardiographic abnormalities in adults from the Brazilian longitudinal study of adults’ health
#Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.
Smiling has been previously shown to improve stress responses. We replicated and expanded this work by testing whether smiling helps with a potent real-world stressor: a vaccination-like needle injection. We also extended past research by examining grimacing, a facial expression known to naturally occur during stress and pain and one that shares some of the… Continue reading #Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.
Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study
Many studies reporting coronavirus disease 2019 (COVID-19) complications have involved case series or small cohorts that could not establish a causal association with COVID-19 or provide risk estimates in different care settings. We sought to study all possible complications of COVID-19 to confirm previously reported complications and to identify potential complications not yet known.. ..Among… Continue reading Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study
Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of acute IS patients with high-grade CAS. Methods: From January 1, 2007,… Continue reading Association between Pre-Existing #Coronary Artery Disease and 5-Year Mortality in #Stroke Patients with High-Grade Carotid Artery Stenosis
Poor outcome of #SARS-CoV-2 infection in patients with severe #asthma on biologic therapy
It is unclear whether asthma and asthma medications increase or decrease the risk of severe COVID-19, and this is particularly true for patients with severe asthma receiving biologics. Objectives The aim of this study was to assess incidence and disease course of COVID-19 in patients with severe asthma on biologic therapy (omalizumab, mepolizumab, reslizumab, benralizumab,… Continue reading Poor outcome of #SARS-CoV-2 infection in patients with severe #asthma on biologic therapy
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