Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. Despite the common use of these medications, treatment recommendations for young children remain divergent.. ..Overall, 19 studies (11 randomized; 8 nonrandomized) of 241 138 participants from 7 countries and various health care settings (hospital-based and community-based) were included. Compared with acetaminophen, ibuprofen resulted in reduced … Continue reading Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

..To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia.. ..A total of 224 trials including 29 962 participants were included. High-quality evidence was found in favor of cognitive behavioral therapy (weighted mean difference [WMD], −0.9; 95% CI, −1.4 to −0.3) for pain in the short term and was found in favor of central nervous system depressants … Continue reading Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

#Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial

This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary outcome was response rate, defined as the percentage of participants … Continue reading #Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial

A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

Acupuncture techniques have been in existence for centuries, with roots tied to Eastern Asian medicine. Ease of application, low cost, and minimal side effects make traditional acupuncture a perioperative modality that has been linked to decreased morbidity and mortality in patients undergoing surgical procedures and anesthesia (1). In the United States, in light of the opioid epidemic, there is a strong need to decrease perioperative … Continue reading A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

#SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A–triggered sensory neuronal firing … Continue reading #SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer … Continue reading The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

New Therapy Reduces Chronic Low Back Pain in Large International Study

A new study hasfound that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid treatments for chronic pain,” said John Markman, M.D., director of … Continue reading New Therapy Reduces Chronic Low Back Pain in Large International Study

#IL-4 induces M2 macrophages to produce sustained #analgesia via opioids

IL-4 is a pleiotropic antiinflammatory cytokine, which can be neuroprotective after nervous system injury. The beneficial actions of IL-4 are thought to result from the blunting of action of inflammatory mediators, such as proinflammatory cytokines. Here, we demonstrate that IL-4 induces M2 macrophages to continuously produce opioid peptides and ameliorate pain. IL-4 application at injured nerves in mice shifted F4/80+ macrophages from the proinflammatory M1 … Continue reading #IL-4 induces M2 macrophages to produce sustained #analgesia via opioids

Nutritional Factors, Physical Health and Immigrant Status Are Associated with Anxiety Disorders among Middle-Aged and Older Adults: Findings from Baseline Data of The Canadian Longitudinal Study on Aging (CLSA)

..Of 26,991 participants (49.3% men, 82.5% Canadian born, 58.5% aged 45–65 years), the overall prevalence of self-reported physician diagnosis of anxiety disorders was 8.5%, with immigrants being lower than Canadian-born respondents (6.4% vs. 9.3%, p < 0.001). After accounting for all covariates, the adjusted odds ratio (aOR) for anxiety disorders was lower among immigrants (aOR = 0.77, 95% CI: 0.67–0.88) compared to those who were … Continue reading Nutritional Factors, Physical Health and Immigrant Status Are Associated with Anxiety Disorders among Middle-Aged and Older Adults: Findings from Baseline Data of The Canadian Longitudinal Study on Aging (CLSA)

Altruistic #behaviors relieve physical #pain

..Across 2 pilot studies and 3 experiments, we showed a pain-relieving effect of performing altruistic behaviors. Acting altruistically relieved not only acutely induced physical pain among healthy adults but also chronic pain among cancer patients. Using functional MRI, we found that after individuals performed altruistic actions brain activity in the dorsal anterior cingulate cortex and bilateral insula in response to a painful shock was significantly … Continue reading Altruistic #behaviors relieve physical #pain

Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020

1. Dual-Acting Osteoporosis Drug 2. Expanded Use of Minimally Invasive Mitral Valve Surgery 3. Inaugural Treatment for Transthyretin Amyloid Cardiomyopathy 4. Therapy for Peanut Allergies 5. Closed-Loop Spinal Cord Stimulation 6. Biologics in Orthopaedic Repair 7. Antibiotic Envelope for Cardiac Implantable Device Infection Prevention 8. Bempedoic Acid for Cholesterol Lowering in Statin Intolerant Patients 9. PARP Inhibitors for Maintenance Therapy in Ovarian Cancer 10. Drugs … Continue reading Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020

How the #weather affects the #pain of citizen scientists using a smartphone app

Weather has been thought to affect symptoms in patients with chronic disease since the time of Hippocrates over 2000 years ago. Around three-quarters of people living with arthritis believe their pain is affected by the weather.. ..Precipitation was not associated with an increased odds of a pain event (OR 0.996 (0.989–1.003) per 1 mm daily rainfall amount).. ..This study has demonstrated that higher relative humidity and … Continue reading How the #weather affects the #pain of citizen scientists using a smartphone app