The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer … Continue reading The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

New Therapy Reduces Chronic Low Back Pain in Large International Study

A new study hasfound that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid treatments for chronic pain,” said John Markman, M.D., director of … Continue reading New Therapy Reduces Chronic Low Back Pain in Large International Study

#IL-4 induces M2 macrophages to produce sustained #analgesia via opioids

IL-4 is a pleiotropic antiinflammatory cytokine, which can be neuroprotective after nervous system injury. The beneficial actions of IL-4 are thought to result from the blunting of action of inflammatory mediators, such as proinflammatory cytokines. Here, we demonstrate that IL-4 induces M2 macrophages to continuously produce opioid peptides and ameliorate pain. IL-4 application at injured nerves in mice shifted F4/80+ macrophages from the proinflammatory M1 … Continue reading #IL-4 induces M2 macrophages to produce sustained #analgesia via opioids

Nutritional Factors, Physical Health and Immigrant Status Are Associated with Anxiety Disorders among Middle-Aged and Older Adults: Findings from Baseline Data of The Canadian Longitudinal Study on Aging (CLSA)

..Of 26,991 participants (49.3% men, 82.5% Canadian born, 58.5% aged 45–65 years), the overall prevalence of self-reported physician diagnosis of anxiety disorders was 8.5%, with immigrants being lower than Canadian-born respondents (6.4% vs. 9.3%, p < 0.001). After accounting for all covariates, the adjusted odds ratio (aOR) for anxiety disorders was lower among immigrants (aOR = 0.77, 95% CI: 0.67–0.88) compared to those who were … Continue reading Nutritional Factors, Physical Health and Immigrant Status Are Associated with Anxiety Disorders among Middle-Aged and Older Adults: Findings from Baseline Data of The Canadian Longitudinal Study on Aging (CLSA)

Altruistic #behaviors relieve physical #pain

..Across 2 pilot studies and 3 experiments, we showed a pain-relieving effect of performing altruistic behaviors. Acting altruistically relieved not only acutely induced physical pain among healthy adults but also chronic pain among cancer patients. Using functional MRI, we found that after individuals performed altruistic actions brain activity in the dorsal anterior cingulate cortex and bilateral insula in response to a painful shock was significantly … Continue reading Altruistic #behaviors relieve physical #pain

Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020

1. Dual-Acting Osteoporosis Drug 2. Expanded Use of Minimally Invasive Mitral Valve Surgery 3. Inaugural Treatment for Transthyretin Amyloid Cardiomyopathy 4. Therapy for Peanut Allergies 5. Closed-Loop Spinal Cord Stimulation 6. Biologics in Orthopaedic Repair 7. Antibiotic Envelope for Cardiac Implantable Device Infection Prevention 8. Bempedoic Acid for Cholesterol Lowering in Statin Intolerant Patients 9. PARP Inhibitors for Maintenance Therapy in Ovarian Cancer 10. Drugs … Continue reading Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020

How the #weather affects the #pain of citizen scientists using a smartphone app

Weather has been thought to affect symptoms in patients with chronic disease since the time of Hippocrates over 2000 years ago. Around three-quarters of people living with arthritis believe their pain is affected by the weather.. ..Precipitation was not associated with an increased odds of a pain event (OR 0.996 (0.989–1.003) per 1 mm daily rainfall amount).. ..This study has demonstrated that higher relative humidity and … Continue reading How the #weather affects the #pain of citizen scientists using a smartphone app