Sex- and age-specific genetic analysis of chronic back #pain

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide association study and single nucleotide polymorphism-by-sex interaction analysis for cBP defined as “Back pain for 3+ months” in 202,077 males and 237,754 females … Continue reading Sex- and age-specific genetic analysis of chronic back #pain

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Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial

The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain. Objective To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors. Design, Setting, and Participants The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial is a randomized clinical trial that was conducted from … Continue reading Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial

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#Statin treatment and #muscle symptoms: series of randomised, placebo controlled n-of-1 trials

To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins. Design Series of randomised, placebo controlled n-of-1 trials. Setting Primary care across 50 sites in the United Kingdom, December 2016 to April 2018. Participants 200 participants who had recently stopped or were considering stopping treatment with statins because of muscle symptoms. Interventions Participants were randomised … Continue reading #Statin treatment and #muscle symptoms: series of randomised, placebo controlled n-of-1 trials

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#Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA. Methods People living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to characterize RA disease activity (DAS-28). Participants also completed questionnaires to … Continue reading #Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

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Association of Medical #Stimulants With #Mortality in the US From 2010 to 2017

The role of nonopioids in the drug overdose epidemic in the US is frequently overshadowed. From 2015 to 2016, mortality rates involving cocaine and psychostimulants were smaller than opioids, but were rising faster than opioids.1 We examined individual substances listed on death certificates to better understand stimulant-associated mortality and assess rates over time. https://bit.ly/3oEgFbP Continue reading Association of Medical #Stimulants With #Mortality in the US From 2010 to 2017

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Responsiveness of the PROMIS-29 Scales in Individuals With Chronic Low #Back Pain

..The PROMIS-29 questionnaire assesses seven health-related quality-of-life domains. However, research to evaluate the responsiveness and MCIDs of the PROMS-29 scores in individuals with low back pain is limited. Methods. The study was conducted in physical therapy clinics in Thailand, using validated Thai versions of the study measures. One hundred and eighty-three individuals with chronic low back pain completed the PROMIS-29 at baseline and at 4-weeks … Continue reading Responsiveness of the PROMIS-29 Scales in Individuals With Chronic Low #Back Pain

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#Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.

Smiling has been previously shown to improve stress responses. We replicated and expanded this work by testing whether smiling helps with a potent real-world stressor: a vaccination-like needle injection. We also extended past research by examining grimacing, a facial expression known to naturally occur during stress and pain and one that shares some of the same facial action units as smiling. Participants (n = 231; … Continue reading #Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.

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Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. Despite the common use of these medications, treatment recommendations for young children remain divergent.. ..Overall, 19 studies (11 randomized; 8 nonrandomized) of 241 138 participants from 7 countries and various health care settings (hospital-based and community-based) were included. Compared with acetaminophen, ibuprofen resulted in reduced … Continue reading Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

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Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

..To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia.. ..A total of 224 trials including 29 962 participants were included. High-quality evidence was found in favor of cognitive behavioral therapy (weighted mean difference [WMD], −0.9; 95% CI, −1.4 to −0.3) for pain in the short term and was found in favor of central nervous system depressants … Continue reading Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

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#Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial

This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary outcome was response rate, defined as the percentage of participants … Continue reading #Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial

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A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

Acupuncture techniques have been in existence for centuries, with roots tied to Eastern Asian medicine. Ease of application, low cost, and minimal side effects make traditional acupuncture a perioperative modality that has been linked to decreased morbidity and mortality in patients undergoing surgical procedures and anesthesia (1). In the United States, in light of the opioid epidemic, there is a strong need to decrease perioperative … Continue reading A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

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#SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A–triggered sensory neuronal firing … Continue reading #SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

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