DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body… Continue reading Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
Elevated #Coronary Artery Calcium scores are associated with #tooth loss
This study explores the association between Coronary Artery Calcium (CAC) scores and dental pathology such as missing teeth, the (peri-apical) health status and restoration grade of the teeth, and the grade of alveolar bone loss seen on a dental panoramic radiograph (Orthopantomograph–OPG).. ..212 patients were included. We found a statistically significant association between the number… Continue reading Elevated #Coronary Artery Calcium scores are associated with #tooth loss
Prefrontal– #amygdala circuits in #social decision-making
An increasing amount of research effort is being directed toward investigating the neural bases of social cognition from a systems neuroscience perspective. Evidence from multiple animal species is beginning to provide a mechanistic understanding of the substrates of social behaviors at multiple levels of neurobiology, ranging from those underlying high-level social constructs in humans and… Continue reading Prefrontal– #amygdala circuits in #social decision-making
Effectiveness of #Prone Positioning in Nonintubated Intensive Care Unit Patients With Moderate to Severe Acute Respiratory Distress Syndrome by #Coronavirus Disease 2019
In the treatment for severe acute respiratory distress syndrome (ARDS) from coronavirus disease 2019 (COVID-19), the World Health Organization (WHO) recommends prone positioning (PP) during mechanical ventilation for periods of 12–16 h/d to potentially improve oxygenation and survival. In this prospective observational study, we evaluated the ability of long PP sessions to improve oxygenation in… Continue reading Effectiveness of #Prone Positioning in Nonintubated Intensive Care Unit Patients With Moderate to Severe Acute Respiratory Distress Syndrome by #Coronavirus Disease 2019
Evaluation of Cloth #Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the #COVID-19 Pandemic
..To evaluate the fitted filtration efficiency (FFE) of various consumer-grade and improvised face masks, as well as several popular modifications of medical procedure masks that are intended to improve mask fit or comfort. Design, Setting, and Participants For this study conducted in a research laboratory between June and August 2020, 7 consumer-grade masks and 5… Continue reading Evaluation of Cloth #Masks and Modified Procedure Masks as Personal Protective Equipment for the Public During the #COVID-19 Pandemic
Trial of #Dexamethasone for Chronic Subdural #Hematoma
Chronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.. ..From August 2015 through November 2019, a total of 748 patients were included in the trial after randomization — 375 were assigned to… Continue reading Trial of #Dexamethasone for Chronic Subdural #Hematoma
A global survey of potential acceptance of a #COVID-19 vaccine
Several coronavirus disease 2019 (COVID-19) vaccines are currently in human trials. In June 2020, we surveyed 13,426 people in 19 countries to determine potential acceptance rates and factors influencing acceptance of a COVID-19 vaccine. Of these, 71.5% of participants reported that they would be very or somewhat likely to take a COVID-19 vaccine, and 61.4%… Continue reading A global survey of potential acceptance of a #COVID-19 vaccine
Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).. ..Primary outcomes were incident fatal or nonfatal coronary heart disease (CHD), stroke, and CVD (composite of the 2). Hazard ratios (HRs) per 1-SD higher log CES-D or PHQ-2 adjusted for age, sex, smoking, and diabetes were reported. Results Among… Continue reading Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
#Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.. ..Results Apathy severity increased over time in presymptomatic carriers, but not in non‐carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but… Continue reading #Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
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