Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes.Objective To determine the effect of verapamil on pancreatic beta cell function in children and adolescents with newly… Continue reading Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 DiabetesA Randomized Clinical Trial
Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
BackgroundInsomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI.MethodsPubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among… Continue reading Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and performance outcomes in separate cohorts of women and men adhering to different ETOD.Methods: Thirty exercise-trained women (BMI = 24 ± 3… Continue reading Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
The Internet is a common source of sleep information, but may be subject to commercial bias and misinformation. We compared the understandability, information quality, and presence of misinformation of popular YouTube videos on sleep to videos with credible experts. We identified the most popular YouTube videos on sleep/insomnia and 5 videos from experts. Videos were… Continue reading Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias… Continue reading Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews
Objective To synthesise the evidence on the effects of physical activity on symptoms of depression, anxiety and psychological distress in adult populations.Design Umbrella review.Data sources Twelve electronic databases were searched for eligible studies published from inception to 1 January 2022.Eligibility criteria for selecting studies Systematic reviews with meta-analyses of randomised controlled trials designed to increase… Continue reading Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews
Food Insufficiency, Supplemental Nutrition Assistance Program (SNAP) Status, and 9-Year Trajectory of Cognitive Function in Older Adults: The Longitudinal National Health and Aging Trends Study, 2012–2020
BackgroundDespite findings from cross-sectional studies, how food insecurity experience/Supplemental Nutrition Assistance Program (SNAP) status relates to cognitive decline over time has not been fully understood.ObjectivesWe aimed to investigate the longitudinal associations between food insecurity/SNAP status and cognitive function in older adults (≥65 y).MethodsLongitudinal data from the National Health and Aging Trends Study 2012–2020 were analyzed… Continue reading Food Insufficiency, Supplemental Nutrition Assistance Program (SNAP) Status, and 9-Year Trajectory of Cognitive Function in Older Adults: The Longitudinal National Health and Aging Trends Study, 2012–2020
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