Periodontitis affects more than 1 billion people worldwide but remains largely underdiagnosed. The oral microbiota offers a noninvasive diagnostic window, but studies based on 16S rRNA data have reported heterogeneous and often suboptimal performance. It remains unclear which oral habitat and modeling strategy best support clinical decision making. We analyzed 2,303 adult samples from 33… Continue reading Comparative Diagnostic Performance of Oral Microbial Habitats for Periodontitis
Category: Dentistry
Does #oral #hygiene prevents nosocomial #infections in hospitalized patients? A systematic review and meta-analysis
Background: This study aimed to evaluate the impact of oral hygiene (OH) with chlorhexidine (CHX) on the evolution of nosocomial infections (NI).Material and methods: Electronic searches were carried out in PubMed, Scopus, Cochrane Library, Web of Science, VHL, and Grey Literature databases. Randomized clinical trials were included. Methodological quality and risk of bias were assessed… Continue reading Does #oral #hygiene prevents nosocomial #infections in hospitalized patients? A systematic review and meta-analysis
Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
Periodontitis is known to be associated with type 2 diabetes mellitus (T2DM), and gargling with mouthwash is known to reduce the incidence of periodontitis by inhibiting periodontal pathogens. However, the effects of mouthwash on oral and systemic conditions in patients with T2DM remain unknown. In this study, we investigated the effects of gargling with mouthwash… Continue reading Effects of #mouthwash on #periodontal pathogens and glycemic control in patients with type 2 #diabetes mellitus
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias… Continue reading Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis
Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies
AbstractBackgroundEmerging evidence indicates that poor periodontal health adversely impacts cognition. This review examined the available longitudinal evidence concerning the effect of poor periodontal health on cognitive decline and dementia.MethodsComprehensive literature search was conducted on five electronic databases for relevant studies published until April 2022. Longitudinal studies having periodontal health as exposure and cognitive decline and/or… Continue reading Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies
The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
Alzheimer’s Disease (AD) is the most common form of dementia in older adults and has a devastating impact on the patient’s quality of life, which creates a significant socio-economic burden for the affected individuals and their families. In recent years, studies have identified a relationship between periodontitis and AD. Periodontitis is an infectious/inflammatory disease that… Continue reading The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases
BackgroundThe 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide. To date, vaccines appear to be the only method to prevent and reduce mortality. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26.COV2-S (Janssen-Johnson&Johnson). After vaccination, local and systemic adverse effects can… Continue reading Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
BackgroundOral microbiota are thought to influence blood pressure (BP) regulation. However, epidemiological data supporting this hypothesis are limited. We examined associations between oral microbiota, BP, and incident hypertension in postmenopausal women. Methods and ResultsBaseline (1997–2001) examinations were completed on 1215 women (mean age, 63 years) during which subgingival plaque was collected, BP was measured, and… Continue reading Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Dose-Response Meta-Analysis on #Tooth Loss With the Risk of #Cognitive Impairment and #Dementia
To quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia. DesignLongitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were… Continue reading Dose-Response Meta-Analysis on #Tooth Loss With the Risk of #Cognitive Impairment and #Dementia
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