The etiologies of Parkinson’s disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common… Continue reading Trichloroethylene: An Invisible Cause of Parkinson’s Disease?
SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Exclusion of the left atrial appendage to reduce thromboembolic risk related to atrial fibrillation was first performed surgically in 1949. Over the past 2 decades, the field of transcatheter endovascular left atrial appendage closure (LAAC) has rapidly expanded, with a myriad of devices approved or in clinical development. The number of LAAC procedures performed in… Continue reading SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
Background and aimsObservational studies have linked elevated blood pressure (BP) to impaired cognitive function. However, the functional and structural changes in the brain that mediate the relationship between BP elevation and cognitive impairment remain unknown. Using observational and genetic data from large consortia, this study aimed to identify brain structures potentially associated with BP values… Continue reading Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure
Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults
AbstractBackgroundIt remains unclear whether non–animal-derived dietary protein sources (and therefore vegan diets) can support resistance training-induced skeletal muscle remodeling to the same extent as animal-derived protein sources.MethodsIn Phase 1, 16 healthy young adults (m = 8, f = 8; age: 23 ± 1 y; BMI: 23 ± 1 kg/m2) completed a 3-d dietary intervention (high… Continue reading Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults
Music to improve sleep quality in adults with depression-related insomnia (MUSTAFI): randomized controlled trial
Background Insomnia in depression is common and difficult to resolve. Unresolved depression-related sleep disturbances increase risk of relapse at high costs for individuals and society. Trials have suggested music for insomnia in various populations, but there is little research on the effectiveness of music for depression-related insomnia. Methods We examined the efficacy of a music… Continue reading Music to improve sleep quality in adults with depression-related insomnia (MUSTAFI): randomized controlled trial
Association of Daily Step Patterns With Mortality in US Adults
Importance Previous studies have shown that individuals who regularly walk, particularly 8000 daily steps or more, experience lower mortality. However, little is known about the health benefits of walking intensively only a few days a week.Objective To evaluate the dose-response association between the number of days an individual takes 8000 steps or more and mortality… Continue reading Association of Daily Step Patterns With Mortality in US Adults
META-ANALYSIS: CLUSTER HEADACHE, MIGRAINE HAVE STRONG LINKS TO CIRCADIAN SYSTEM
...For cluster headache, the meta-analysis found a circadian pattern of headache attacks in 71% of people. Attacks peaked in the late hours of the night to early hours of the morning. During the year, people had more attacks in the spring and fall. On the genetic level, cluster headache was associated with two main circadian… Continue reading META-ANALYSIS: CLUSTER HEADACHE, MIGRAINE HAVE STRONG LINKS TO CIRCADIAN SYSTEM
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Highlights•Meat may be an important vehicle for human exposure to extraintestinal pathogenic E. coli strains from food animals.•We present a novel approach for predicting the origins of clinical E. coli isolates.•Approximately 8% of the clinical E. coli isolates in our population appeared to be foodborne zoonotic strains.•Foodborne zoonotic E. coli strains were associated with asymptomatic… Continue reading Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
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