Comparison of #Lemborexant With Placebo and #Zolpidem Tartrate Extended Release for the Treatment of Older Adults With #Insomnia Disorder

..Both doses of lemborexant therapy demonstrated statistically significant greater changes from baseline on objective sleep onset as assessed by latency to persistent sleep (log transformed) that was measured using polysomnography at the end of 1 month of treatment (nights 29 and 30) compared with placebo.. For nights 29 and 30, as measured using polysomnography, the mean change from baseline in sleep efficiency .. and wake-after-sleep … Continue reading Comparison of #Lemborexant With Placebo and #Zolpidem Tartrate Extended Release for the Treatment of Older Adults With #Insomnia Disorder

Influence of #sleep problems and co-occurring musculoskeletal pain on long-term prognosis of chronic low #backpain: the HUNT Study

Compared with persons without sleeplessness, persons who often/always experienced sleeplessness had a lower probability of recovery from chronic LBP (RR 0.65, 95% CI 0.57 to 0.74 in women and RR 0.81, 95% CI 0.69 to 0.95 in men). Although there was no clear evidence of statistical interaction between sleeplessness and co-occurring musculoskeletal pain, women and men who often/always experienced sleeplessness and had ≥5 additional chronic pain sites … Continue reading Influence of #sleep problems and co-occurring musculoskeletal pain on long-term prognosis of chronic low #backpain: the HUNT Study

Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study

..We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care. ..We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with … Continue reading Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study

#Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults. A 10-year cohort

..Three insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, and daytime dysfunction for at least 3 d/wk at baseline ..Cox regressions showed that 3 insomnia symptoms were associated with increased risk of total #CVD, with respective adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.09 (95% CI 1.07–1.11), 1.07 (95% CI 1.05–1.09), and 1.13 (95% CI … Continue reading #Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults. A 10-year cohort

Reducing #Suicidal Ideation Through #Insomnia Treatment (REST-IT): A Randomized Clinical Trial

..Zolpidem-CR had a robust anti-insomnia effect, especially in patients with the most severe insomnia symptoms. No significant treatment effect was observed on the Scale for Suicide Ideation (least squares mean estimate=−0.56, SE=0.83, 95% CI=−2.19, 1.08), but the reduction in scores was significantly positively related to improvement in insomnia after accounting for the effect of other depression symptoms. The C-SSRS indicated that zolpidem-CR had a significant … Continue reading Reducing #Suicidal Ideation Through #Insomnia Treatment (REST-IT): A Randomized Clinical Trial