Several clinical and large population studies indicate that women are more salt-sensitive than men, yet the precise mechanisms by which the sexually dimorphic onset manifests remains incompletely understood. Here, we evaluate recent epidemiological data and highlight current knowledge from studies investigating sex-specific mechanisms of salt-sensitive blood pressure (SSBP). Emerging evidence indicates that women of all… Continue reading Salt Sensitivity of Blood Pressure in Women
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women’s Survey Prospective Cohort Study
Children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.ObjectiveTo examine differential mother-offspring and father-offspring associations in body composition in early childhood.MethodsA total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort… Continue reading Parent-Offspring Associations in Body Composition: Findings From the Southampton Women’s Survey Prospective Cohort Study
Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.Objective To determine whether torsemide results in decreased mortality compared with furosemide among patients hospitalized for heart failure.Design, Setting, and Participants TRANSFORM-HF was an open-label, pragmatic randomized trial that recruited 2859 participants hospitalized with… Continue reading Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Cannabis use is increasing among adults with children in the home particularly in states with cannabis legalization for medical (MCL) and/or recreational use (RCL), relative to states where cannabis use remains illegal at the state level. Exposure to secondhand smoke is a key risk factor for asthma among children. The objective of the current study… Continue reading Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Straight from the heart
Lipids called ceramides may be better predictors of cardiovascular problems than cholesterol. Doctors and pharma are waking up to their potential https://www.science.org/content/article/straight-heart-mysterious-lipids-may-predict-cardiac-problems-better-cholesterol
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia
In gout, hyperuricemia promotes urate crystal deposition, which stimulates the NLRP3 inflammasome and interleukin-1β (IL-1β)–mediated arthritis. Incident gout without background hyperuricemia is rarely reported. To identify hyperuricemia-independent mechanisms driving gout incidence and progression, we characterized erosive urate crystalline inflammatory arthritis in a young female patient with normouricemia diagnosed as having sufficient and weighted classification criteria… Continue reading Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia
Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
BACKGROUNDBetween 1999 and 2009 in the United Kingdom, 82,429 men between 50 and 69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer was diagnosed in 2664 men. Of these men, 1643 were enrolled in a trial to evaluate the effectiveness of treatments, with 545 randomly assigned to receive active monitoring, 553… Continue reading Fifteen-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Multiple lines of evidence support the value of moderate fever to host survival, but the mechanisms involved remain unclear. This is difficult to establish in warm-blooded animal models, given the strict programmes controlling core body temperature and the physiological stress that results from their disruption. Thus, we took advantage of a cold-blooded teleost fish that… Continue reading Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis
Background Dietary modification is a cornerstone of cardiovascular disease (CVD) prevention. A Mediterranean diet has been associated with a lower risk of CVD but no systematic reviews have evaluated this relationship specifically in women.Objective To determine the association between higher versus lower adherence to a Mediterranean diet and incident CVD and total mortality in women.Methods… Continue reading Primary prevention of cardiovascular disease in women with a Mediterranean diet: systematic review and meta-analysis
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