American Society of Hematology 2020 guidelines for management of venous #thromboembolism: treatment of deep vein #thrombosis and pulmonary #embolism

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs in ∼1 to 2 individuals per 1000 each year, corresponding to ∼300 000 to 600 000 events in the United States annually.. ..Strong recommendations include the use of thrombolytic therapy for patients with PE and hemodynamic compromise, use of an international normalized ratio (INR) range of 2.0 to 3.0 over a lower INR … Continue reading American Society of Hematology 2020 guidelines for management of venous #thromboembolism: treatment of deep vein #thrombosis and pulmonary #embolism

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Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence

The objectives of this study were to assess the effect of obstructive sleep apnea (OSA) on the risk of acute pulmonary embolism (PE), hospital outcomes including mortality, and PE recurrence.. ..Of 25,038 patients, 3,184 (13%) had OSA and 283 (1.1%) experienced PE. Frequency of PE in patients with and without OSA was 2.4% versus 0.9% (odds ratio [OR], 2.51; 95% confidence interval [CI], 1.9–3.3; P … Continue reading Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence

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Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability

Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in patients with a moderate C-PTP ..We performed a prospective study in which pulmonary embolism was considered to be ruled out without further testing … Continue reading Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability

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Underuse of Clinical Decision Rules and d-#Dimer in Suspected Pulmonary #Embolism: A Nationwide Survey of the Veterans Administration Health Care System

The diagnosis of pulmonary embolism (PE) remains a challenge. CT pulmonary angiography (CTPA) for suspected PE has become the primary imaging modality, but concerns regarding overutilization, overdiagnosis, radiation, and costs have led to algorithms that combine a clinical decision rule (CDR) and highly sensitive d-dimer to identify patients in whom PE can be safely excluded without further studies. ..The overwhelming majority of respondents (85%) did … Continue reading Underuse of Clinical Decision Rules and d-#Dimer in Suspected Pulmonary #Embolism: A Nationwide Survey of the Veterans Administration Health Care System

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