High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable. MethodsWe tested the association of LCT genotype with milk consumption (for validation) and with… Continue reading Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure
The prognostic importance of admission systolic blood pressure (SBP) in heart failure with preserved ejection fraction (HFpEF) is elusive. We aimed to clarify the pathophysiological differences between patients categorized with admission SBP among HFpEF patients. Methods and resultsWe studied 1008 inpatients from PURSUIT-HFpEF, a multicentre prospective observational registry. We classified patients as having elevated (>140… Continue reading Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure
Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus
Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cytokines, chemokines, and costimulatory molecules. Persistent activation of pDCs has been demonstrated in a number of autoimmune diseases. To… Continue reading Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus
The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
Upper respiratory tract infections (URTIs) are common, mostly self-limiting, but result in inappropriate antibiotic prescriptions. Poor sleep is cited as a factor predisposing to URTIs, but the evidence is unclear. ObjectiveTo systematically review whether sleep duration and quality influence the frequency and duration of URTIs. MethodsThree databases and bibliographies of included papers were searched for… Continue reading The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
#Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
Our aim was to analyze and compare the effects of three different long-term treatments on anthropometric profiles, eating behaviors, anxiety and depression levels, and quality of life of groups of adults with obesity. Methods: The 43 participants in the study were randomly assigned to one of three groups: the education and health group (EH, n… Continue reading #Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas
Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available. Objective:To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas. Design:Retrospective cohort study. (ClinicalTrials.gov: NCT03919734) Setting:Two hospitals in… Continue reading Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas
The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats
Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer’s disease (AD). Preclinical data corroborating this association are largely from studies of male animals exposed acutely or subchronically to high levels of isolated fractions of TRAP. What remains unclear is whether chronic exposure to ambient TRAP modifies AD risk and the influence of… Continue reading The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats
#Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown. ObjectivesThe aim of this study was to explore the role of dysregulation in the AT metabolome on vascular redox signaling and cardiovascular outcomes. MethodsA screen was conducted for metabolites differentially secreted by thoracic AT… Continue reading #Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Effects of #music participation for mild #cognitive impairment and #dementia: A systematic review and meta-analysis
To examine randomized controlled trials with active music-making interventions, in which older adults with probable mild cognitive impairment (MCI) or dementia physically participate in music, and their effects on cognitive functioning, emotional well-being, and social engagement. Participating in music-making is engaging and has shown diverse benefits. Additionally, this review categorized the music activities of each… Continue reading Effects of #music participation for mild #cognitive impairment and #dementia: A systematic review and meta-analysis
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