Evaluation of Adiposity and Cognitive Function in Adults

Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association …

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#Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease

Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown. ObjectivesThe aim of this study was to explore the role of dysregulation in the AT metabolome on vascular redox signaling and cardiovascular outcomes. MethodsA screen was conducted for metabolites differentially secreted by thoracic AT …

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Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study

..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese …

Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study

Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid

..Since in humans consumption of sugar-sweetened beverages has been widely implicated, we investigated whether the mode of ingestion (solid or liquid) had different impacts on body weight regulation and glucose homeostasis Consumption of sucrose-sweetened water, but not equivalent levels of solid sucrose, led to body fat gain in C57BL/6 mice. Glucose intolerance was positively correlated …

Continue reading Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid