Nasal high flow (NHF) has demonstrated efficacy in relieving dyspnea in various patients with hypoxemic and hypercapnic respiratory failure. It may also reduce dyspnea in patients with acute severe asthma in the emergency department (ED). The aim of the study was to compare the efficacy of NHF with conventional oxygen therapy (COT) in improving dyspnea… Continue reading Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Data SourceWe conducted a systematic review and searched MEDLINE, EMBASE and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke. Study SelectionTitles,… Continue reading The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
Nongenetic Determinants of Risk for Early-Onset #Colorectal Cancer
Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by… Continue reading Nongenetic Determinants of Risk for Early-Onset #Colorectal Cancer
Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Prospective evidence on associations between diet quality indices and lung cancer risk is limited, particularly among older women. ObjectivesWe investigated associations between 4 diet quality indices [Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index 2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH)] and lung cancer incidence and mortality in the… Continue reading Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Dynamic Associations Between #Anxiety, #Depression, and #Tobacco Use in Older Adults: Results From The Irish Longitudinal Study on Ageing
Evidence supports moderate-to-large reductions in anxiety, depression, and perceived stress after smoking cessation; however, much of the available evidence has focused on young adults. Therefore, this study quantified associations between smoking and smoking cessation on prevalent and incident generalised anxiety disorder (GAD) and major depression (MDD) in a nationally representative sample of Irish older adults.… Continue reading Dynamic Associations Between #Anxiety, #Depression, and #Tobacco Use in Older Adults: Results From The Irish Longitudinal Study on Ageing
Face #masks effectively limit the probability of #SARS-CoV-2 transmission
Airborne transmission by droplets and aerosols is important for the spread of viruses. Face masks are a well-established preventive measure, but their effectiveness for mitigating SARS-CoV-2 transmission is still under debate. We show that variations in mask efficacy can be explained by different regimes of virus abundance and related to population-average infection probability and reproduction… Continue reading Face #masks effectively limit the probability of #SARS-CoV-2 transmission
XCR1+ type 1 conventional #dendritic cells drive liver pathology in non-alcoholic #steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this disease are poorly understood. Here, using single-cell transcriptomic analysis,… Continue reading XCR1+ type 1 conventional #dendritic cells drive liver pathology in non-alcoholic #steatohepatitis
Collectivism predicts #mask use during #COVID-19
Since its outbreak, COVID-19 has impacted world regions differentially. Whereas some regions still record tens of thousands of new infections daily, other regions have contained the virus. What explains these striking regional differences? We advance a cultural psychological perspective on mask usage, a precautionary measure vital for curbing the pandemic. Four large-scale studies provide evidence… Continue reading Collectivism predicts #mask use during #COVID-19
Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context of genetic variants that carry elevated risk can advance novel treatment approaches for these disorders. Objective To test the hypothesis that mitochondrial compensation is associated with the variable penetrance of schizophrenia in the 22q11.2 deletion syndrome (22q11DS). Design, Setting, and Participants This… Continue reading Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia
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