AbstractObjective While there are several well-established environmental risk factors for rheumatoid arthritis (RA), a paucity of evidence exists linking environmental toxicants with RA prevalence. We aimed to examine the associations between various environmental toxicants and RA among adults in the U.S. general population while adjusting for non-heritable risk factors.Design Cross-sectional study.Setting National Health and Nutrition Examination Survey conducted… Continue reading Polycyclic aromatic hydrocarbons and risk of rheumatoid arthritis: a cross-sectional analysis of the National Health and Nutrition Examination Survey, 2007–2016
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Background:Chronic kidney disease (CKD) accelerates vascular calcification via phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of circulating small extracellular vesicles (sEVs) between the kidneys and VSMCs and uncovered relevant sEV-propagated microRNAs (miRNAs) and their biological signaling pathways.Methods and Results:We established CKD models in rats and mice by adenine-induced tubulointerstitial fibrosis.… Continue reading Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
Increased risk of osteoarthritis in patients with atopic disease
Objectives To determine the incidence of osteoarthrits (OA) in patients with atopic disease compared with matched non-exposed patients.Methods We conducted a retrospective cohort study with propensity score matching using claims data from Optum’s de-identified Clinformatics Data Mart (CDM) (January 2003 to June 2019) and electronic health record data from the Stanford Research Repository (STARR) (January 2010 to… Continue reading Increased risk of osteoarthritis in patients with atopic disease
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Highlights•PCOS-sons are often obese and have dyslipidemia•miRNAs altered in the serum of PCOS-sons and women with PCOS targets PCOS-risk genes•Small RNAs present in sperm imply transgenerational transmission of phenotype in mice•Shared miRNAs between mouse sperm of F1–F3 generations and human serum are revealedSummaryThe transgenerational maternal effects of polycystic ovary syndrome (PCOS) in female progeny are being… Continue reading Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
AbstractBackgroundImpaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and… Continue reading Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD).Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish… Continue reading Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes
Mobile phone calls, genetic susceptibility, and new-onset hypertension: results from 212 046 UK Biobank participants
The relationship between mobile phone use for making or receiving calls and hypertension risk remains uncertain. We aimed to examine the associations of mobile phone use for making or receiving calls and the use frequency with new-onset hypertension in the general population, using data from the UK Biobank.Methods and resultsA total of 212 046 participants… Continue reading Mobile phone calls, genetic susceptibility, and new-onset hypertension: results from 212 046 UK Biobank participants
Association between dietary inflammation index and hypertension in participants with different degrees of liver steatosis
BackgroundThe prevalence of hypertension (HTN) is higher in patients with non-alcoholic fatty liver disease (NAFLD). Inflammation is the key link between HTN and NAFLD. Systemic inflammation can be dramatically increased by inflammatory diet intake. However, whether controlling the inflammatory diet intake in NAFLD patients could affect the occurrence of HTN still remains unknown. Our aim… Continue reading Association between dietary inflammation index and hypertension in participants with different degrees of liver steatosis
Lifestyle mediators of associations among siestas, obesity, and metabolic health
ObjectiveThe aim of this study was to determine the association between siestas/no siestas and obesity, considering siesta duration (long: >30 minutes, short: ≤30 minutes), and test whether siesta traits and/or lifestyle factors mediate the association of siestas with obesity and metabolic syndrome (MetS).MethodsThis was a cross-sectional study of 3275 adults from a Mediterranean population (the Obesity, Nutrigenetics,… Continue reading Lifestyle mediators of associations among siestas, obesity, and metabolic health
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