Objective: We aimed to assess the association of proton-pump inhibitor (PPI) use with muscle strength in older adults.Methods: All 1940-born residents of Turku, Finland were surveyed during 2016 and 2017 as part of the New Turku Older Adults Study. Associations between PPI use, regardless of dosing pattern, and physical function were analyzed using Welch's t-test,… Continue reading Association Between Proton-Pump Inhibitors and Muscle Strength in Older Adults: A Population-Based Analysis
Tag: muscle
Unraveling physical performance over time in hospitalized older patients with walking limitation: the role of ultrasound-derived vastus lateralis muscle thickness
Acute hospitalization is a critical stressor that often leads to functional decline in older patients, highlighting the need for simple markers to identify at-risk individuals. Ultrasound is a feasible bedside tool for muscle mass assessment and has been proposed as a marker of physical function, but its prognostic value remains unclear. This study aimed to… Continue reading Unraveling physical performance over time in hospitalized older patients with walking limitation: the role of ultrasound-derived vastus lateralis muscle thickness
Effect of relative handgrip strength and back muscle strength on the incidence of hypertension: 18-year follow-up in a population-based cohort study
Substantial evidence supports an association between physical #exercises and #hypertension. However, the role of muscle #strength, such as hand grip strength (HGS) and back muscle strength (BMS), remains unclear in this relationship. This study investigated whether low BMS and HGS accelerated incident hypertension in a population-based prospective study. A total 3,038 non-hypertensive subjects aged 40-69… Continue reading Effect of relative handgrip strength and back muscle strength on the incidence of hypertension: 18-year follow-up in a population-based cohort study
Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The association of perturbed skeletal muscle metabolism with #ICU acquired weakness (ICUAW) is not clear. The objective of the present study was to characterise temporal changes in skeletal #muscle mitochondrial function, #ATP concentration, and substrate utilisation during and up to 6 months post ICU admission in critically ill patients, and to delineate mechanisms underpinning ICUAW… Continue reading Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
The current literature on the chronic effects of static stretching (SS) exercises on muscle strength and power is unclear and controversial.ObjectiveWe aimed to examine the chronic effects of SS exercises on muscle strength and power as well as flexibility in healthy individuals across the lifespan.DesignSystematic review with meta-analysis of (randomized) controlled trials.Data SourcesA systematic literature… Continue reading Chronic Effects of Static #Stretching Exercises on Muscle #Strength and Power in Healthy Individuals Across the Lifespan: A Systematic Review with Multi-level Meta-analysis
The #Quadriceps: A Physician’s In-Depth Look at a #Muscular Marvel
As a physician with a passion for human anatomy, I’ve always been intrigued by the intricacies of the human body. Today, we venture into the world of the quadriceps, a powerful group of muscles that is pivotal for movement and strength. Join me in this exploration of the anatomy and clinical relevance of the quadriceps… Continue reading The #Quadriceps: A Physician’s In-Depth Look at a #Muscular Marvel
Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
AbstractBackgroundObesity and loss of muscle mass are emerging as risk factors for dementia, but the role of adiposity infiltrating skeletal muscles is less clear. Skeletal muscle adiposity increases with older age and especially among Black women, a segment of the US population who is also at higher risk for dementia.MethodsIn 1634 adults (69–79 years, 48% women,… Continue reading Increase in skeletal muscular adiposity and cognitive decline in a biracial cohort of older men and women
Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
AbstractBackgroundImpaired muscle function has been identified as a risk factor for declining cognitive function and cardiovascular health, both of which are risk factors for late-life dementia (after 80 years of age). We examined whether hand grip strength and timed-up-and-go (TUG) performance, including their change over 5 years, were associated with late-life dementia events in older women and… Continue reading Impaired muscle function, including its decline, is related to greater long-term late-life dementia risk in older women
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