Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women

Variants in the tau gene (MAPT) region are associated with breast cancer in women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–). MethodsTo identify novel genes associated with tau-related pathology, we conducted two genome-wide association studies (GWAS) for AD, one among 10,340 ε4– women in the Alzheimer's Disease Genetics Consortium (ADGC) and …

Continue reading Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women

Gender Dysphoria and Suicidal Ideation: Clinical Observations from a Psychiatric Emergency Service

Adolescent gender dysphoria is increasingly common. There has been documentation of the association of gender dysphoria with numerous other psychiatric conditions as well as attempted and completed suicide. The literature is unsettled on specific risk factors for self-harm within this population. Though there are published recommendations, there appears to be a need for additional clinical …

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Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation

Neuropathic pain affects millions of people worldwide, yet the molecular mechanisms of how it develops and persists are poorly understood. Given that males have historically been utilized as the primary sex in preclinical studies, less is known about the female neuroinflammatory response to injury, formation of pain, or response to pain-relieving therapies. Macrophages contribute to …

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Experiences of Work-Family Conflict and #Mental Health Symptoms by Gender Among Physician Parents During the #COVID-19 Pandemic

The COVID-19 pandemic has placed increased strain on health care workers and disrupted childcare and schooling arrangements in unprecedented ways. As substantial gender inequalities existed in medicine before the pandemic, physician mothers may be at particular risk for adverse professional and psychological consequences. Objective To assess gender differences in work-family factors and mental health among …

Continue reading Experiences of Work-Family Conflict and #Mental Health Symptoms by Gender Among Physician Parents During the #COVID-19 Pandemic

Sex- and age-specific genetic analysis of chronic back #pain

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide association study and single nucleotide polymorphism-by-sex interaction analysis for cBP defined as “Back …

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