Skeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old. The 10 year CVD incidence increased significantly across the baseline SMI tertiles (p<0.001). Baseline SMM showed a significant… Continue reading Skeletal #muscle mass in relation to 10 year #cardiovascular disease incidence among middle aged and older adults: the ATTICA study
Author: aledopress
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Temperature and #mental health: Evidence from the spectrum of mental health outcomes
This paper characterizes the link between ambient temperatures and a broad set of mental health outcomes. We find that higher temperatures increase emergency department visits for mental illness, suicides, and self-reported days of poor mental health. Specifically, cold temperatures reduce negative mental health outcomes while hot temperatures increase them. Our estimates reveal no evidence of… Continue reading Temperature and #mental health: Evidence from the spectrum of mental health outcomes
Association of #Testosterone Therapy With Risk of Venous #Thromboembolism Among Men With and Without #Hypogonadism
..A total of 39https://bit.ly/2qGlfy0622 men (mean [SD] age, 57.4 [14.2] years) were enrolled in the study, and 3110 men (7.8%) had evidence of hypogonadism. In age-adjusted models, testosterone therapy use in all case periods was associated with a higher risk of VTE in men with (odds ratio [OR], 2.32; 95% CI, 1.97-2.74) and without (OR,… Continue reading Association of #Testosterone Therapy With Risk of Venous #Thromboembolism Among Men With and Without #Hypogonadism
Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020
1. Dual-Acting Osteoporosis Drug 2. Expanded Use of Minimally Invasive Mitral Valve Surgery 3. Inaugural Treatment for Transthyretin Amyloid Cardiomyopathy 4. Therapy for Peanut Allergies 5. Closed-Loop Spinal Cord Stimulation 6. Biologics in Orthopaedic Repair 7. Antibiotic Envelope for Cardiac Implantable Device Infection Prevention 8. Bempedoic Acid for Cholesterol Lowering in Statin Intolerant Patients 9.… Continue reading Cleveland Clinic Unveils Top 10 Medical #Innovations for 2020
#Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Human neutrophils are the most abundant circulating leukocytes and contribute to acute and chronic inflammatory disorders. Neutrophil apoptosis is programed cell death to maintain immune homeostasis, but inflammatory responses to infections or tissue injury disrupt neutrophil death program, leading to many diseases. Precise control of neutrophil apoptosis may resolve inflammation to return immune homeostasis. Here,… Continue reading #Nanoparticle-induced #neutrophil apoptosis increases survival in #sepsis and alleviates neurological damage in #stroke
Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume. ..At all points, these scores were associated… Continue reading Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort
The Predictive Performance of Objective Measures of #physical Activity Derived From Accelerometry Data for 5-Year All-Cause Mortality in #Older Adults: National Health and Nutritional Examination Survey 2003–2006
Declining physical activity (PA) is a hallmark of aging. Wearable technology provides reliable measures of the frequency, duration, intensity, and timing of PA.. In univariate logistic regression, the total activity count was the best predictor of 5-year mortality (Area under the Curve (AUC) = 0.771) followed by age (AUC = 0.758). Overall, 9 of the… Continue reading The Predictive Performance of Objective Measures of #physical Activity Derived From Accelerometry Data for 5-Year All-Cause Mortality in #Older Adults: National Health and Nutritional Examination Survey 2003–2006
Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role… Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
#Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies
..We assessed the association of incident dementia and clinical Alzheimer's disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. ..There were 3728 incident cases… Continue reading #Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies
